中国地方病学杂志
中國地方病學雜誌
중국지방병학잡지
CHINESE JOURNAL OF ENDEMIOLOGY
2010年
4期
384-386
,共3页
莫非%渠巍%夏曙华%喻茂娟%涂飞
莫非%渠巍%夏曙華%喻茂娟%塗飛
막비%거외%하서화%유무연%도비
大豆%硒%螺旋藻属%氟%铝%血红蛋白类
大豆%硒%螺鏇藻屬%氟%鋁%血紅蛋白類
대두%서%라선조속%불%려%혈홍단백류
Soy beans%Selenium%Spindina%Fluorine%Aluminum%Hemoglobins
目的 观察大豆、硒、螺旋藻对氟铝联合中毒大鼠血红蛋白(Hb)的改变.方法 84只SD大鼠,按体质量随机分为对照组、高铝组、高氟组、高氟铝组、高氟铝强化大豆组、高氟铝强化硒组、高氟铝加螺旋藻组,每组12只.对照组、高铝组的饲料含氟量为5.2 mg/kg,含铝量为6.8 mg/kg,其他各组的含氟量为106mg/kg,含铝量为19.7 mg/kg;对照组、高氟组的饮水含氟量为0.69 mg/L,含铝量为0.20 mg/L,其他各组的含氟量为0.69 mg/L,含铝量为90.2 mg/L).饲养90 d后,取全血测定Hb.结果 对照组、高氟组、高铝组、高氟铝组的Hb分别为(160.8±6.3)、(142.2±15.9)、(156.1±4.9)、(145.2±6.2)g/L.氟对Hb有影响(F=29.56,P<0.05).高氟铝组、高氟铝加大豆组、高氟铝加硒组、高氟铝加螺旋藻组的Hb水平分别为(145.2±6.2)、(150.7±17.7)、(156.8±14.5)、(154.5±17.8)g/L,虽然Hb水平有升高,但差异无统计学意义(χ2=3.304,P>0.05).结论 高氟能引起大鼠血红蛋白不同程度的降低,过量铝对大鼠Hb无影响;铝没有拮抗或加强氟中毒对大鼠Hb的干扰作用.大豆、硒和螺旋藻均对氟铝联合中毒大鼠Hb有升高趋势,但未见明显的拮抗作用.
目的 觀察大豆、硒、螺鏇藻對氟鋁聯閤中毒大鼠血紅蛋白(Hb)的改變.方法 84隻SD大鼠,按體質量隨機分為對照組、高鋁組、高氟組、高氟鋁組、高氟鋁彊化大豆組、高氟鋁彊化硒組、高氟鋁加螺鏇藻組,每組12隻.對照組、高鋁組的飼料含氟量為5.2 mg/kg,含鋁量為6.8 mg/kg,其他各組的含氟量為106mg/kg,含鋁量為19.7 mg/kg;對照組、高氟組的飲水含氟量為0.69 mg/L,含鋁量為0.20 mg/L,其他各組的含氟量為0.69 mg/L,含鋁量為90.2 mg/L).飼養90 d後,取全血測定Hb.結果 對照組、高氟組、高鋁組、高氟鋁組的Hb分彆為(160.8±6.3)、(142.2±15.9)、(156.1±4.9)、(145.2±6.2)g/L.氟對Hb有影響(F=29.56,P<0.05).高氟鋁組、高氟鋁加大豆組、高氟鋁加硒組、高氟鋁加螺鏇藻組的Hb水平分彆為(145.2±6.2)、(150.7±17.7)、(156.8±14.5)、(154.5±17.8)g/L,雖然Hb水平有升高,但差異無統計學意義(χ2=3.304,P>0.05).結論 高氟能引起大鼠血紅蛋白不同程度的降低,過量鋁對大鼠Hb無影響;鋁沒有拮抗或加彊氟中毒對大鼠Hb的榦擾作用.大豆、硒和螺鏇藻均對氟鋁聯閤中毒大鼠Hb有升高趨勢,但未見明顯的拮抗作用.
목적 관찰대두、서、라선조대불려연합중독대서혈홍단백(Hb)적개변.방법 84지SD대서,안체질량수궤분위대조조、고려조、고불조、고불려조、고불려강화대두조、고불려강화서조、고불려가라선조조,매조12지.대조조、고려조적사료함불량위5.2 mg/kg,함려량위6.8 mg/kg,기타각조적함불량위106mg/kg,함려량위19.7 mg/kg;대조조、고불조적음수함불량위0.69 mg/L,함려량위0.20 mg/L,기타각조적함불량위0.69 mg/L,함려량위90.2 mg/L).사양90 d후,취전혈측정Hb.결과 대조조、고불조、고려조、고불려조적Hb분별위(160.8±6.3)、(142.2±15.9)、(156.1±4.9)、(145.2±6.2)g/L.불대Hb유영향(F=29.56,P<0.05).고불려조、고불려가대두조、고불려가서조、고불려가라선조조적Hb수평분별위(145.2±6.2)、(150.7±17.7)、(156.8±14.5)、(154.5±17.8)g/L,수연Hb수평유승고,단차이무통계학의의(χ2=3.304,P>0.05).결론 고불능인기대서혈홍단백불동정도적강저,과량려대대서Hb무영향;려몰유길항혹가강불중독대대서Hb적간우작용.대두、서화라선조균대불려연합중독대서Hb유승고추세,단미견명현적길항작용.
Objective To observe the effects of soybean,selenium and spirulina on hemoglobin(Hb)of rats intoxicated with fluorine and aluminiums.Methods According to body weight,84 SD rats were randomly divided into control group,high aluminum group,high fluorine group,high fluorine-aluminum group,high fluorine-aluminium intoxicated rats strengthened with soybean group,high fluorine-aluminium intoxicated rats strengthened with selenium group and high fluorine-aluminium intoxicated rats strengthened with spirulina group,12 in each group.Rats in the control group and the high aluminum group were fed with feed containing 5.2 mg/kg of fluorine and 6.8 mg/kg of aluminum.In other groups,fluorine wag 106 mg/Kg and aluminum 19.7 mg/kg.Fluorine and aluminum concentration in the drinking water of the control group and the high fluorine group were 0.69 mg/L and 0.20 mg/L,respectively.In other groups' drinking water,these values were 0.69 mg/L and 90.2 mg/L,respectively.Ninety days later,Hb concentration of the whole blood was tested.Results Hb concentration of the control group,the high aluminum group,the high fluorine group,and the high fluorine-aluminum group were (160.8±6.3),(142.2±15.9),(156.1±4.9)and(145.2±6.2)g/L,respectively.Fluorine had an effect on the concentration of Hb(F=29.56,P<0.05).The Hb concentration of the high fluorine-aluminum group,the strengthened with soybean group,the strengthened with selenium group and the strengthened with Spirulina group were(145.2±6.2),(150.7±17.7),(156.8±14.5),(154.5±17.8)g/L,respectively.Though the concentration of Hb had increased,there was no significant difference between the four groups(χ2=3.304,P>0.05).Conclusions High-dose fluorine could cause varied decrease in the concentration of Hb.However,aluminum has neitherantagonistic effect nor synergistic effect on the Hb of fluorotic Rat.Soybean,selenium and Spirulina show a trend to increase fluorotic rat's Hb,but they has no evident antagonistic effect.
