CAJ | 학술논문

目的评价0.1%双氯芬酸钠透明质酸钠滴眼液辅助治疗急性变态反应性结膜炎的有效性及安全性的临床评价.方法对90例(180只眼)急性变态反应性结膜炎患者.包括季节性与常年性变态反应性结膜炎,随机分成三组.A组:对照一组,单用0.05%依美斯汀滴眼液;B组:对照二组,0.05%依美斯汀滴眼液联合0.1%普拉洛芬滴眼液;C组:试验组0.05%依美斯汀滴眼液联合0.1%双氯芬酸钠透明质酸钠滴眼液,三组每种用药均为每日3次.分别于治疗前与治疗后1d、4d、7d、14d随访,评估眼痒、流泪、畏光、异物感等症状与睑结膜乳头和滤泡、分泌物、结膜充血、结膜水肿、角膜缘改变、角膜上皮改变、球周组织水肿等体征,评价有效率及治愈率,并观察用药后眼部不适及副反应.结果三组患者的一般情况、治疗前症状与体征评分差异均无统计学意义(P＞0.05).A组、B组与C组的治疗有效率在治疗后第1天分别为6.7%、56.7%与60.0%,第4天分别为20.0%、100.0%与96.7%,第7天分别为53.3%、100.0%与100.0%,第14天分别为73.3%、100.0%与100.0%.治疗第14天治愈率分别为10.0%、73.3%与63.3%.两两比较各随访时间点的有效率与治愈率,A组与B组的组间差异均具有统计学意义(P均＝0.000),A组与C组组间的差异均具有统计学意义(P均=0.000),而B组与C组在治疗后各随访时间点的有效率与治愈率相当,差异无统计学意义(P=0.918、0.147、0.058、0.0405＞0.05).各试验组未见用药后的眼部不适及副反应.结论非甾体类消炎药能快速、有效缓解急性变态反应性结膜炎的症状与体征,其中,0.1%双氯芬酸钠透明质酸钠滴眼液与同类进口滴眼液的疗效相当,是一种有效、安全又经济的变态反应性结膜炎的辅助治疗药物.
목적 평개0.1%쌍록분산납투명질산납적안액보조치료급성변태반응성결막염적유효성급안전성적림상평개.방법 대90례(180지안)급성변태반응성결막염환자.포괄계절성여상년성변태반응성결막염,수궤분성삼조.A조:대조일조,단용0.05%의미사정적안액;B조:대조이조,0.05%의미사정적안액연합0.1%보랍락분적안액;C조:시험조0.05%의미사정적안액연합0.1%쌍록분산납투명질산납적안액,삼조매충용약균위매일3차.분별우치료전여치료후1d、4d、7d、14d수방,평고안양、류루、외광、이물감등증상여검결막유두화려포、분비물、결막충혈、결막수종、각막연개변、각막상피개변、구주조직수종등체정,평개유효솔급치유솔,병관찰용약후안부불괄급부반응.결과 삼조환자적일반정황、치료전증상여체정평분차이균무통계학의의(P＞0.05).A조、B조여C조적치료유효솔재치료후제1천분별위6.7%、56.7%여60.0%,제4천분별위20.0%、100.0%여96.7%,제7천분별위53.3%、100.0%여100.0%,제14천분별위73.3%、100.0%여100.0%.치료제14천치유솔분별위10.0%、73.3%여63.3%.량량비교각수방시간점적유효솔여치유솔,A조여B조적조간차이균구유통계학의의(P균＝0.000),A조여C조조간적차이균구유통계학의의(P균=0.000),이B조여C조재치료후각수방시간점적유효솔여치유솔상당,차이무통계학의의(P=0.918、0.147、0.058、0.0405＞0.05).각시험조미견용약후적안부불괄급부반응.결론 비치체류소염약능쾌속、유효완해급성변태반응성결막염적증상여체정,기중,0.1%쌍록분산납투명질산납적안액여동류진구적안액적료효상당,시일충유효、안전우경제적변태반응성결막염적보조치료약물.
Objective To evaluate the clinical values of 0.1% Diclofenac Sodium eye drops,one of non-steroidal anti-inflammatory drugs (NSAIDs),on the treatment of acute allergic conjunctivitis.Methods Ninety patients (180 eyes) with acute allergic conjunctivitis,including seasonal allergic conjunctivitis and perennial allergic conjunctivitis,were enrolled in the study.A randomized and controlled study was adopted 0.05% Emedastine Difumarate eye drops for the group A (first control group),0.1% Pranoprofen eye drops plus 0.05% Emedastine Difumarate eye drops for the group B (second control group) and 0.1% Diclofenac Sodium eye drops plus 0.05% Emedastine Difumarate eye drops for the group C (test group),three times a day for each.The symptoms and signs were evaluated before and after the treatment at 1st day,4th day,7th day and 14th day,respectively,and the side effects were observed.Results There was no significant difference between the group A,B and C in the general state,mean scores of symptoms and signs before the treatment.After the administration,the efficacy rates in the group A,B and C were 6.7%,56.7% and 60.0% at 1st day,20.0%,100.0% and 96.7% at 4th day,53.3%,100.0% and 100.0% at 7th day,and 73.7%,100.0% and 100.0% at 14th day respectively.By further analysis,there was significant difference between the group A and B in the efficacy rates and the cure rates after the administration,as well as the group A and C (all P=0.000),meanwhile,there was no statistical significance between the group B and C (P=0.918,0.147,0.058 and 0.0405 ＞0.05).Furthermore,there was no obvious discomfortableness and adverse reaction observed in the three test group.Conclusions NSAIDs can rapidly and effectively assist to relieve the symptoms and signs of acute allergic conjunctivitis.0.1% Dielofenae Sodium eye drops,which is similar with the imported NSAIDs eye drops in the efficacy and cure rates,have an efficacy and safety to control the inflammation of allergic conjunctivitis.