中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2011年
3期
256-257
,共2页
郜宪林%刘广才%朱海献%李炳义%胡会婷
郜憲林%劉廣纔%硃海獻%李炳義%鬍會婷
고헌림%류엄재%주해헌%리병의%호회정
短暂性脑缺血发作%高半胱氨酸血症%叶酸
短暫性腦缺血髮作%高半胱氨痠血癥%葉痠
단잠성뇌결혈발작%고반광안산혈증%협산
Transient ischemic attack%Hyperhomocysteinaemia%Folic acid
目的 观察叶酸治疗对合并高半胱氨酸血症(Hcy)的短暂性脑缺血发作(TIA)患者血浆高半胱氨酸(HCA)水平及预后的影响.方法 将129例合并Hcy的TIA患者应用随机数字法随机分为2组,对照组(n=64)只给予常规治疗,观察组(n=65)在常规治疗的基础上给予叶酸治疗,对比分析2组患者治疗前及治疗后3个月HCA水平的变化及其1年内完全缓解率及完全性脑卒中发生率.结果 初发TIA患者Hcy的发生率高达41.4%.治疗3个月后,观察组血浆HCA显著降低[(14.27±6.13)μmol/L,(24.99±6.87)μmol/L,t=2.799,P＜0.01],而对照组血浆HCA无明显变化[(24.68±6.89)μmol/L,(25.68±7.11)μmol/L,t=2.735,P＜0.01].1年后,观察组完全性脑卒中发生率显著低于对照组(9.8%,25.0%,x2=4.849,P＜0.05),TIA症状完全缓解率高于对照组(73.8%,50.0%,x2=7.253,P＜0.01),且无明显不良反应.结论 叶酸治疗可有效降低TIA患者的血浆HCA水平,改善患者的预后.
目的 觀察葉痠治療對閤併高半胱氨痠血癥(Hcy)的短暫性腦缺血髮作(TIA)患者血漿高半胱氨痠(HCA)水平及預後的影響.方法 將129例閤併Hcy的TIA患者應用隨機數字法隨機分為2組,對照組(n=64)隻給予常規治療,觀察組(n=65)在常規治療的基礎上給予葉痠治療,對比分析2組患者治療前及治療後3箇月HCA水平的變化及其1年內完全緩解率及完全性腦卒中髮生率.結果 初髮TIA患者Hcy的髮生率高達41.4%.治療3箇月後,觀察組血漿HCA顯著降低[(14.27±6.13)μmol/L,(24.99±6.87)μmol/L,t=2.799,P＜0.01],而對照組血漿HCA無明顯變化[(24.68±6.89)μmol/L,(25.68±7.11)μmol/L,t=2.735,P＜0.01].1年後,觀察組完全性腦卒中髮生率顯著低于對照組(9.8%,25.0%,x2=4.849,P＜0.05),TIA癥狀完全緩解率高于對照組(73.8%,50.0%,x2=7.253,P＜0.01),且無明顯不良反應.結論 葉痠治療可有效降低TIA患者的血漿HCA水平,改善患者的預後.
목적 관찰협산치료대합병고반광안산혈증(Hcy)적단잠성뇌결혈발작(TIA)환자혈장고반광안산(HCA)수평급예후적영향.방법 장129례합병Hcy적TIA환자응용수궤수자법수궤분위2조,대조조(n=64)지급여상규치료,관찰조(n=65)재상규치료적기출상급여협산치료,대비분석2조환자치료전급치료후3개월HCA수평적변화급기1년내완전완해솔급완전성뇌졸중발생솔.결과 초발TIA환자Hcy적발생솔고체41.4%.치료3개월후,관찰조혈장HCA현저강저[(14.27±6.13)μmol/L,(24.99±6.87)μmol/L,t=2.799,P＜0.01],이대조조혈장HCA무명현변화[(24.68±6.89)μmol/L,(25.68±7.11)μmol/L,t=2.735,P＜0.01].1년후,관찰조완전성뇌졸중발생솔현저저우대조조(9.8%,25.0%,x2=4.849,P＜0.05),TIA증상완전완해솔고우대조조(73.8%,50.0%,x2=7.253,P＜0.01),차무명현불량반응.결론 협산치료가유효강저TIA환자적혈장HCA수평,개선환자적예후.
Objective To observe the therapeutic effect of folic acid on transient ischemic attack(TIA)patients with homocysteinaemia (Hcy ). Methods 129 patients of primary TIA with Hcy were divided into two groups randomly. The observation group ( n = 65 )was administered with conventional therapy and folic acid, and the control group ( n=64 ) was only given conventional therapy. The variances of the plasma HCA level three months later were compared, and remission rate of TIA and complete stroke incidence one year later were analyzed between two groups. Results The Hcy incidence rate of TIA patients was up to 41.4%. Three months later, the plasma HCA level of observation group was lower than control group( ( 14.27 ± 6. 13 ) μmol/L vs (24.99 ± 6.87 )μmol/L, t=2.799, P＜0. 01 ) ,and much lower than that of the control group post-treatment ( ( 14. 27 ±6. 13)μmol/L vs (24.68 ± 6.89) μmol/L, t = 2.735, P ＜ 0.01 ). One year later, the complete stroke incidence of TIA in observation group was lower than that of the control group(9.8% vs 25.0%, P＜0.05 ) ,and complete remission rate was higher than the latter(73.8% vs 50.0%, P ＜ 0. 01 ). Conclusion Folic acid can decrease the plasma HCA level of TIA patients with Hcy efficiently,and improve the prognosis of such patients.
