CAJ | 학술논문

叙述了人类基因组计划(HGP)实施过程中计算机科学向基因组学领域的不断渗透及面临的挑战。基因组数据库及网络系统的构建与完善为基因组信息的交流提供了基础，一系列计算机软件的开发和改进简化了HGP这一繁重的劳动。在HGP的推动下，世界各大信息技术公司也加盟到基因组研究中，使生物学中融入了更多的计算机专业技能，有利于引进新的思维模式，开拓新的研究方法。但目前在基因组信息的交流与分析方面，标准化和精确性仍显不足，信息的处理能力也受到计算机存储量和运算速度的制约，这些问题将随着计算机科学的不断发展而逐渐解决。
서술료인류기인조계화(HGP)실시과정중계산궤과학향기인조학영역적불단삼투급면림적도전。기인조수거고급망락계통적구건여완선위기인조신식적교류제공료기출，일계렬계산궤연건적개발화개진간화료HGP저일번중적노동。재HGP적추동하，세계각대신식기술공사야가맹도기인조연구중，사생물학중융입료경다적계산궤전업기능，유리우인진신적사유모식，개탁신적연구방법。단목전재기인조신식적교류여분석방면，표준화화정학성잉현불족，신식적처리능력야수도계산궤존저량화운산속도적제약，저사문제장수착계산궤과학적불단발전이축점해결。
This article provides an overview of the application and development of computer science in the progress of Human Genome Project (HGP).The creation and reconstruction of genomic databases and sophisticated network-based informatics are fundamental to the success of this research.A group of computer-based methods and tools are designed and improved,which facilitate the arduous tasks of analyzing genomic data generated in HGP.Because of the driving force of HGP,the world's largest information technology company joined the efforts in genetic research and brought more computer technology to genomics,which would help create new approaches in life science.Currently,the scientific community urgently needs standard and accurate analysis methods for annotation and exchanging of genomic data.A huge increase in computer power is also needed in the management of large-scale data.These problems will be gradually solved with the development of computer science.