CAJ | 학술논문

目的研究醉鱼草(Buddleja lindeyana)的活性成分.方法应用多种色谱技术分离纯化,用IR,MS和NMR等谱学方法解析化合物结构.结果与结论从醉鱼草(Buddleja lindeyana)的全草分离到5个化合物,其中三个为环烯醚萜苷.它们的结构为:6-氧-阿魏酰筋骨草苷(1),赤式-6-氧-4＇-(3-甲氧基-4-羟基苯丙三醇-8")-阿魏酰筋骨草苷(2),苏式-6-氧-4＇-(3-甲氧基-4-羟基苯丙三醇-8")-阿魏酰筋骨草苷(3),二十四烷酸-α-单甘油脂(4),半乳糖醇(5).上述成分均为首次从醉鱼草中得到.且化合物1,2和3对神经细胞有保护作用.
목적연구취어초(Buddleja lindeyana)적활성성분.방법응용다충색보기술분리순화,용IR,MS화NMR등보학방법해석화합물결구.결과여결론종취어초(Buddleja lindeyana)적전초분리도5개화합물,기중삼개위배희미첩감.타문적결구위:6-양-아위선근골초감(1),적식-6-양-4＇-(3-갑양기-4-간기분병삼순-8")-아위선근골초감(2),소식-6-양-4＇-(3-갑양기-4-간기분병삼순-8")-아위선근골초감(3),이십사완산-α-단감유지(4),반유당순(5).상술성분균위수차종취어초중득도.차화합물1,2화3대신경세포유보호작용.
Aim To study the chemical constituents of Buddleja lindeyana. Methods The constituents were separated and purified by different methods of chromatography, and their structures were elucidated by IR, MS and NMR. Results Three iridoid glycosides and two other compounds were isolated from Buddleja lindeyana. Their structures were elucidated to be 6-O-feruloylajugol ( 1 ), erythro-6-oxo-4′-( 3-methoxyl-4-hydroxyphenylglycol-8")-feruloylaj-ugol ( 2 ), threo-6-oxo-4′-(3-methoxyl-4-hydroxyphenylglycol-8")-feruloylajugol ( 3 ), tetra-cosanoic acid 2,3-dihydroxypropyl ester (4), and galactitol (5). Conclusion All the compounds have been isolated from this plant for the first time. Compounds 1, 2 and 3 have protective effect agains MPP+ -induced apoptosis.