CAJ | 학술논문

背景:进行性体质量减轻和体力下降是晚期恶性肿瘤常见的并发症,是影响患者生活质量的一个重要因素.目的:探讨中药复方益气消症冲剂配合应用抗肿瘤药物治疗(化疗)对于晚期恶性肿瘤治疗效果及生活质量的影响.设计:随机对照观察.单位:北京大学临床肿瘤学院.对象:选择1999-06/2002-03在北京肿瘤医院中西医结合病房住院治疗的晚期肺癌、乳腺癌或肠癌患者61例.方法:将61例恶性肿瘤患者随机分为治疗组(中药复方益气消症冲剂加化疗)34例,对照组(单纯化疗)27例,观察两组疗效、带瘤生存时间及生活质量的不同.两组疗效比较按照世界卫生组织制定的实体瘤临床疗效标准:完全缓解,部分缓解,稳定,进展.对治疗前与治疗两个疗程后两组患者进行影像学检查,评价疗效.体力分级根据美国东部肿瘤协作组评定标准,对两组治疗前后进行分级,治疗后分级下降者为改善,分级上升者为加重.主要观察指标:①两组患者的治疗效果比较.②带瘤生存时间比较.③治疗前后的体力状况及气虚症状变化.结果:61例患者均进入结果分析.①两组疗效比较:治疗组有效率高于对照组(两组部分缓解率、稳定率及进展率分别为36%,7%;52%,67%;12%,26%,P＜0.05).②带瘤生存时间比较:截止至2002-03,治疗组平均带瘤生存时间大于对照组[(20.73±19.74),(11.93±5.08)个月,P＜0.05].③体力分级:治疗组治疗后体力分级状况好于对照组[治疗组改善9例(26%),稳定25例(74%),加重0例;对照组改善1例(4%),稳定25例(93%),加重1例(4%),P＜0.05].④中医气虚症状变化比较:治疗前后比较两组气虚症状,治疗组具汗出气短,少气懒言,倦怠乏力等症状明显减少(治疗前后分别为20,9;17,9;20,13例),对照组则稳定或增加(治疗前后分别为13,13;14,17;18,20例).结论:益气消症冲剂配合化疗治疗晚期恶性肿瘤与对照组相比不仅可提高疗效,还可以改善生活质量,延长带瘤生存时间. 揹景:進行性體質量減輕和體力下降是晚期噁性腫瘤常見的併髮癥,是影響患者生活質量的一箇重要因素.目的:探討中藥複方益氣消癥遲劑配閤應用抗腫瘤藥物治療(化療)對于晚期噁性腫瘤治療效果及生活質量的影響.設計:隨機對照觀察.單位:北京大學臨床腫瘤學院.對象:選擇1999-06/2002-03在北京腫瘤醫院中西醫結閤病房住院治療的晚期肺癌、乳腺癌或腸癌患者61例.方法:將61例噁性腫瘤患者隨機分為治療組(中藥複方益氣消癥遲劑加化療)34例,對照組(單純化療)27例,觀察兩組療效、帶瘤生存時間及生活質量的不同.兩組療效比較按照世界衛生組織製定的實體瘤臨床療效標準:完全緩解,部分緩解,穩定,進展.對治療前與治療兩箇療程後兩組患者進行影像學檢查,評價療效.體力分級根據美國東部腫瘤協作組評定標準,對兩組治療前後進行分級,治療後分級下降者為改善,分級上升者為加重.主要觀察指標:①兩組患者的治療效果比較.②帶瘤生存時間比較.③治療前後的體力狀況及氣虛癥狀變化.結果:61例患者均進入結果分析.①兩組療效比較:治療組有效率高于對照組(兩組部分緩解率、穩定率及進展率分彆為36%,7%;52%,67%;12%,26%,P＜0.05).②帶瘤生存時間比較:截止至2002-03,治療組平均帶瘤生存時間大于對照組[(20.73±19.74),(11.93±5.08)箇月,P＜0.05].③體力分級:治療組治療後體力分級狀況好于對照組[治療組改善9例(26%),穩定25例(74%),加重0例;對照組改善1例(4%),穩定25例(93%),加重1例(4%),P＜0.05].④中醫氣虛癥狀變化比較:治療前後比較兩組氣虛癥狀,治療組具汗齣氣短,少氣懶言,倦怠乏力等癥狀明顯減少(治療前後分彆為20,9;17,9;20,13例),對照組則穩定或增加(治療前後分彆為13,13;14,17;18,20例).結論:益氣消癥遲劑配閤化療治療晚期噁性腫瘤與對照組相比不僅可提高療效,還可以改善生活質量,延長帶瘤生存時間.
배경:진행성체질량감경화체력하강시만기악성종류상견적병발증,시영향환자생활질량적일개중요인소.목적:탐토중약복방익기소증충제배합응용항종류약물치료(화료)대우만기악성종류치료효과급생활질량적영향.설계:수궤대조관찰.단위:북경대학림상종류학원.대상:선택1999-06/2002-03재북경종류의원중서의결합병방주원치료적만기폐암、유선암혹장암환자61례.방법:장61례악성종류환자수궤분위치료조(중약복방익기소증충제가화료)34례,대조조(단순화료)27례,관찰량조료효、대류생존시간급생활질량적불동.량조료효비교안조세계위생조직제정적실체류림상료효표준:완전완해,부분완해,은정,진전.대치료전여치료량개료정후량조환자진행영상학검사,평개료효.체력분급근거미국동부종류협작조평정표준,대량조치료전후진행분급,치료후분급하강자위개선,분급상승자위가중.주요관찰지표:①량조환자적치료효과비교.②대류생존시간비교.③치료전후적체력상황급기허증상변화.결과:61례환자균진입결과분석.①량조료효비교:치료조유효솔고우대조조(량조부분완해솔、은정솔급진전솔분별위36%,7%;52%,67%;12%,26%,P＜0.05).②대류생존시간비교:절지지2002-03,치료조평균대류생존시간대우대조조[(20.73±19.74),(11.93±5.08)개월,P＜0.05].③체력분급:치료조치료후체력분급상황호우대조조[치료조개선9례(26%),은정25례(74%),가중0례;대조조개선1례(4%),은정25례(93%),가중1례(4%),P＜0.05].④중의기허증상변화비교:치료전후비교량조기허증상,치료조구한출기단,소기라언,권태핍력등증상명현감소(치료전후분별위20,9;17,9;20,13례),대조조칙은정혹증가(치료전후분별위13,13;14,17;18,20례).결론:익기소증충제배합화료치료만기악성종류여대조조상비불부가제고료효,환가이개선생활질량,연장대류생존시간.
BACKGROUND: Progressive body mass losses and physical strength decrease are common complications of malignant tumors, and they are important factors that affect the quality of life of the patients.OBJECTIVE: To probe into the curative effect of a Chinese herbal compound Yiqi Xiaozheng granules combined with antitumor drugs in the treatment of malignant tumors and its effect on the quality of life.DESIGN: A randomized controlled observation.SETTING:Clinical Tumor College of Peking University.PARTICIPANT: Totally 61 patients with malignant pulmonary carcinoma,breast or intestinal carcinoma hospitalized in the Wards of Integrated Traditional Chinese and Western Medicine of Beijing Cancer Hospital from June 1999 to March 2002 were recruited.METHODS: Altogether 61 cases of malignant tumor were randomized into the treatment group (treated with Chinese herbal compound Yiqi Xiaozheng granules supplemented with chemotherapy)(n=34) and the control group (treated with only chemotherapy was used)(n=27). The difference in curative effect, survival period with tumor and the quality of life of the two groups were observed. The comparison of the curative effects of the two groups was performed according to Clinical Curative Effect Criteria for Solid Tumors stipulated by World Health Organization: completely response, partly response, stable disease, and progressive disease. X-ray examination was performed on the patients before the therapy and two courses of treatment after the therapy to evaluate the curative effect. Physical strength grading was made according to the evaluation criteria of Eastern Oneology Cooperative Group of the United States. The two groups were graded before and after the treatment. The group with decreased grade after the treatment was considered to be improving, but the group with increased grade after the treatment was considered to be worsening.symptom before and after therapyparison of the curative effect of the two groups: The cure rate of the treatment group was higher than that of the control group (partial response rate,stability rate and progression rate of the two groups was 36% ,7% ;52%,survival with tumors: The mean period of survival with tumors of the treatment group was longer than that of the control group until March 2002ing: Physical strength grading status was better after the therapy in the treatment group than that in the control group [ In the treatment group, 9cases (26%)were ameliorated, 25 (74%)appeared stable , none was aggravated; in the control group, 1 case (4%) was ameliorated, 25(93%) appeared of qi-deficiency symptoms in traditional Chinese medicine before and after the treatment between the two groups. Symptoms such as sweating and qi deficiency manifested as disclination to talk, listlessness, debility, etc. were significantly reduced in the treatment group (The numbers of cases before and after the treatment were 20, 9; 17,9; 20,13 respectively). In the control group, the cases either were stable or showed an increase in symptoms (There were 13, 13; 14, 17; 18, 20 respectively before and after treatment).CONCLUSION: Compared with the control group, in the treatment of malignant tumors, Yiqi Xiaozheng granules supplemented with chemotherapy not only enhanced curative effect, but also improved the quality of life and prolonged the period of survival with tumors.