CAJ | 학술논문

目的:探讨血管紧张素Ⅱ(ATⅡ)、干扰素γ(IFN-γ)、白细胞介素(IL)-4及IL-17水平与原发性高血压患者早期肾损害的关系.方法:68例原发性高血压患者依据尿白蛋白排泄率检测结果分为早期肾损害组和无肾损害组,健康体检者24例作为对照组.采用放射免疫法检测血浆ATⅡ水平,ELISA法检测血清中IFN-γ、IL-4和IL-17水平.结果:早期肾损害组ATⅡ、IFN-γ和IL-17水平增高,与无肾损害组和对照组相比差异有统计学意义;3组IL-4水平变化小,差异无统计学意义;ATⅡ水平与IFN-γ、IL-17水平呈正相关,而与IL-4水平无相关性.结论:原发性高血压患者的高ATⅡ水平使效应性T 淋巴细胞亚群活性发生变化,导致Th1、Th17的功能上调与早期肾损害的发生和发展.
목적:탐토혈관긴장소Ⅱ(ATⅡ)、간우소γ(IFN-γ)、백세포개소(IL)-4급IL-17수평여원발성고혈압환자조기신손해적관계.방법:68례원발성고혈압환자의거뇨백단백배설솔검측결과분위조기신손해조화무신손해조,건강체검자24례작위대조조.채용방사면역법검측혈장ATⅡ수평,ELISA법검측혈청중IFN-γ、IL-4화IL-17수평.결과:조기신손해조ATⅡ、IFN-γ화IL-17수평증고,여무신손해조화대조조상비차이유통계학의의;3조IL-4수평변화소,차이무통계학의의;ATⅡ수평여IFN-γ、IL-17수평정정상관,이여IL-4수평무상관성.결론:원발성고혈압환자적고ATⅡ수평사효응성T 림파세포아군활성발생변화,도치Th1、Th17적공능상조여조기신손해적발생화발전.
Objective:To evaluate the relationship between the levels of IFN-γ, IL-4 , IL-17 and early kidney injury in patients with hypertension. Methods:Sixty-eight hypertensive patients were divided into two groups by urinary albumin excretion rate(UAER): group one consisting of 22 cases with early kidney injury and group two consisting of 46 cases without kidney injury. The control group consists of 24 cases without hypertension and kidney injury.The levels of plasma angiotensin II were measured using radioimmunoassay and that of IFN-γ, IL-4 and IL-17 were measured using ELISA.Results:Angiotensin Ⅱ, IFN-γ and IL-17 levels were found to be sharply increased in group one compared with group two and the control group. The levels of IL-4 were no difference. The levels of angiotensin II were positively correlated with the levels of IFN-γ and IL-17 and negatively correlated with the levels of IL-4. Conclusions: High angiotensin II in the patients of hypertension induced the upregulation of Th1 and Th17,which promoted early kidney injury.