CAJ | 학술논문

以二甲亚砜(DMSO)为溶剂,用多巴胺(Dopamine)胺解聚(苯乙烯-alt-马来酸酐)(P(St-alt-Man))制备双亲交替共聚物P(St-alt-Ma-Dopa).在选择性溶剂(N,N-二甲基甲酰胺(DMF)/水中对P(St-alt-Ma-Dopa)进行溶液自组装,用紫外分光光度计(UV)、透射电镜(TEM)、荧光探针技术、zeta电位仪等技术研究了添加剂(HCl,NaOH或NaCl)对P(St-alt-Ma-Dopa)自组装行为的影响及其胶体粒子的乳化性能.结果表明,P(St-alt-Ma-Dopa)链在选择性溶剂(DMF/水)中可自组装形成球状胶体颗粒,其临界聚集水含量(CWC)明显大于P(St-alt-Man).体系的pH值、盐浓度等对P(St-alt-Ma-Dopa)胶体粒子的性质(粒子大小、zeta电位、亲疏水性等)有较大的影响,引入多巴胺结构使交替共聚物胶体粒子的乳化性能有所提高.
이이갑아풍(DMSO)위용제,용다파알(Dopamine)알해취(분을희-alt-마래산항)(P(St-alt-Man))제비쌍친교체공취물P(St-alt-Ma-Dopa).재선택성용제(N,N-이갑기갑선알(DMF)/수중대P(St-alt-Ma-Dopa)진행용액자조장,용자외분광광도계(UV)、투사전경(TEM)、형광탐침기술、zeta전위의등기술연구료첨가제(HCl,NaOH혹NaCl)대P(St-alt-Ma-Dopa)자조장행위적영향급기효체입자적유화성능.결과표명,P(St-alt-Ma-Dopa)련재선택성용제(DMF/수)중가자조장형성구상효체과립,기림계취집수함량(CWC)명현대우P(St-alt-Man).체계적pH치、염농도등대P(St-alt-Ma-Dopa)효체입자적성질(입자대소、zeta전위、친소수성등)유교대적영향,인입다파알결구사교체공취물효체입자적유화성능유소제고.
Using dimethylsulfoxide (DMSO) as solvent, an amphiphilic alternating copolymer P(St-aft-Ma-Dopa) was prepared by the ammonolysis of P(St-aft-Man) with dopamine. The influences of additives (HCl, NaOH, or NaCl) on the characteristics of P(St-aft-Ma-Dopa) colloid particles after the self-assembly of the copolymer in the selective solvent N,N-dimethylformamide (DMF)/H_2O were studied by UV spectrophotometer, transmission electron microscopy (TEM), zeta potential measurements, and fluorescence probe. Results show that P(St-aft-Ma-Dopa) can self-assemble into spherical particles and its critical water content (CWC) is larger than that of P(St-aft-Man). The size, zeta potential, and hydrophilic-hydrophobic property of these colloid particles showed a series of regular changes after the addition of HCl, NaOH, or NaCl. The emulsification of P(St-aft-Ma-Dopa) colloid particles was improved because of the presence of dopamine.