CAJ | 학술논문

目的:检测2型糖尿病患者眼房水中血管内皮生长因子(Vascular endothelial growth factor,VEGF)和白细胞介素-6(Interleukin-6,IL-6)的含量,并探讨其临床意义.方法:在白内障手术过程中获取66例2型糖尿病患者的房水,采用双抗体夹心酶联免疫吸附(ELISA)法测定VEGF和IL-6的含量.根据手术后散瞳眼底检查和眼底荧光素血管造影检查确定糖尿病视网膜病变的分期.实验组分为:无糖尿病视网膜病变组(NDR)21例、单纯型糖尿病性视网膜病变组(BDR)26例、增生型糖尿病性视网膜病变组(PDR)19例,正常对照组为健康的老年性白内障患者20例.结果:NDR组、BDR组、PDR组的房水VEGF含量分别为(240.30±26.15)pg/ml、(292.27±58.91)pg/ml、(477.41±91.01)pg/ml,IL-6含量分别为(160.83±33.41)pg/ml、(238.60±62.23)pg/ml、(389.13±90.35)pg/ml,对照组房水VEGF含量为(140.58±26.27)pg/ml、IL-6含量为(82.72±21.53)pg/ml,对照组与实验组比较差异均有统计学意义(F=113.67,P＜0.01;F=106.53,P＜0.01).实验组房水中的VEGF与IL-6含量有相关性(r=0.995,P＜0.01);糖尿病患者的病程与房水中VEGF(r=0.792,0.826,0.841均P＜0.01)、IL-6(r=0.829,0.817,0.896均P＜0.01)含量有相关性.结论:VEGF、IL-6在糖尿病视网膜病变的形成过程中有重要作用,且两者之间有相关性.
목적:검측2형당뇨병환자안방수중혈관내피생장인자(Vascular endothelial growth factor,VEGF)화백세포개소-6(Interleukin-6,IL-6)적함량,병탐토기림상의의.방법:재백내장수술과정중획취66례2형당뇨병환자적방수,채용쌍항체협심매련면역흡부(ELISA)법측정VEGF화IL-6적함량.근거수술후산동안저검사화안저형광소혈관조영검사학정당뇨병시망막병변적분기.실험조분위:무당뇨병시망막병변조(NDR)21례、단순형당뇨병성시망막병변조(BDR)26례、증생형당뇨병성시망막병변조(PDR)19례,정상대조조위건강적노년성백내장환자20례.결과:NDR조、BDR조、PDR조적방수VEGF함량분별위(240.30±26.15)pg/ml、(292.27±58.91)pg/ml、(477.41±91.01)pg/ml,IL-6함량분별위(160.83±33.41)pg/ml、(238.60±62.23)pg/ml、(389.13±90.35)pg/ml,대조조방수VEGF함량위(140.58±26.27)pg/ml、IL-6함량위(82.72±21.53)pg/ml,대조조여실험조비교차이균유통계학의의(F=113.67,P＜0.01;F=106.53,P＜0.01).실험조방수중적VEGF여IL-6함량유상관성(r=0.995,P＜0.01);당뇨병환자적병정여방수중VEGF(r=0.792,0.826,0.841균P＜0.01)、IL-6(r=0.829,0.817,0.896균P＜0.01)함량유상관성.결론:VEGF、IL-6재당뇨병시망막병변적형성과정중유중요작용,차량자지간유상관성.