中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
18期
2733-2734
,共2页
胡延良%孙志芳%范春霞%张金杰%张安华
鬍延良%孫誌芳%範春霞%張金傑%張安華
호연량%손지방%범춘하%장금걸%장안화
益生菌%快速肠道准备方法%系统性炎症反应综合征
益生菌%快速腸道準備方法%繫統性炎癥反應綜閤徵
익생균%쾌속장도준비방법%계통성염증반응종합정
Probiotics%Rapid bowel preparation methods%Systemic inflammatory response syndrome
目的 观察快速肠道准备方法联合益生菌用于术前肠道准备的效果.方法 124例择期行手术治疗结直肠癌患者按照肠道准备方式不同随机分为益生菌组(65例)和对照组(59例),对照组于术前采用传统的3d肠道准备方法;益生菌组于术前采用1d快速肠道准备方法,并给予益生菌制剂口服.观察两组患者的体温、心率变化及术后第1、8天检测全血细菌DNA比值,观察外周血白细胞计数及全身炎症反应综合征(SIRS)和并发症发生情况.结果 益生菌组术后发热时间(4.15±0.89)d、心率(89.91±8.59)次/min,明显低于对照组的(6.34±1.12)d、(104.27±11.67)次/min(t=11.52、20.07,均P＜0.05);益生菌组白细胞计数恢复正常时间(4.59±0.29)d、全血细菌DNA阳性率3.30％( 2/65),与对照组的(7.24±0.24)d、26.67％( 8/59)差异均有统计学意义(t=5.07,x2=34.68,均P＜0.05);益生菌组SIRS发生率72.31％ (47/65),与对照组的76.27％ (45/59)差异无统计学意义(P＞0.05);两组切口感染发生率分别为4.35％ (3/65)、3.39％(2/59),腹腔感染发生率分别为1.45％( 1/65)、1.69％ (1/59),两组差异均无统计学意义(均P＞0.05).结论 快速肠道准备方法联合益生菌制剂能提高肠道准备效果,有利于患者术后早期炎性反应的恢复.
目的 觀察快速腸道準備方法聯閤益生菌用于術前腸道準備的效果.方法 124例擇期行手術治療結直腸癌患者按照腸道準備方式不同隨機分為益生菌組(65例)和對照組(59例),對照組于術前採用傳統的3d腸道準備方法;益生菌組于術前採用1d快速腸道準備方法,併給予益生菌製劑口服.觀察兩組患者的體溫、心率變化及術後第1、8天檢測全血細菌DNA比值,觀察外週血白細胞計數及全身炎癥反應綜閤徵(SIRS)和併髮癥髮生情況.結果 益生菌組術後髮熱時間(4.15±0.89)d、心率(89.91±8.59)次/min,明顯低于對照組的(6.34±1.12)d、(104.27±11.67)次/min(t=11.52、20.07,均P＜0.05);益生菌組白細胞計數恢複正常時間(4.59±0.29)d、全血細菌DNA暘性率3.30％( 2/65),與對照組的(7.24±0.24)d、26.67％( 8/59)差異均有統計學意義(t=5.07,x2=34.68,均P＜0.05);益生菌組SIRS髮生率72.31％ (47/65),與對照組的76.27％ (45/59)差異無統計學意義(P＞0.05);兩組切口感染髮生率分彆為4.35％ (3/65)、3.39％(2/59),腹腔感染髮生率分彆為1.45％( 1/65)、1.69％ (1/59),兩組差異均無統計學意義(均P＞0.05).結論 快速腸道準備方法聯閤益生菌製劑能提高腸道準備效果,有利于患者術後早期炎性反應的恢複.
목적 관찰쾌속장도준비방법연합익생균용우술전장도준비적효과.방법 124례택기행수술치료결직장암환자안조장도준비방식불동수궤분위익생균조(65례)화대조조(59례),대조조우술전채용전통적3d장도준비방법;익생균조우술전채용1d쾌속장도준비방법,병급여익생균제제구복.관찰량조환자적체온、심솔변화급술후제1、8천검측전혈세균DNA비치,관찰외주혈백세포계수급전신염증반응종합정(SIRS)화병발증발생정황.결과 익생균조술후발열시간(4.15±0.89)d、심솔(89.91±8.59)차/min,명현저우대조조적(6.34±1.12)d、(104.27±11.67)차/min(t=11.52、20.07,균P＜0.05);익생균조백세포계수회복정상시간(4.59±0.29)d、전혈세균DNA양성솔3.30％( 2/65),여대조조적(7.24±0.24)d、26.67％( 8/59)차이균유통계학의의(t=5.07,x2=34.68,균P＜0.05);익생균조SIRS발생솔72.31％ (47/65),여대조조적76.27％ (45/59)차이무통계학의의(P＞0.05);량조절구감염발생솔분별위4.35％ (3/65)、3.39％(2/59),복강감염발생솔분별위1.45％( 1/65)、1.69％ (1/59),량조차이균무통계학의의(균P＞0.05).결론 쾌속장도준비방법연합익생균제제능제고장도준비효과,유리우환자술후조기염성반응적회복.
Objective To explore the effect of rapid intestinal preparation combined with probiotics in bowel preparation before operation.Methods 124 colorectal cancer patients were divided into the probiotic group(65 cases) and control group(59 cases).Control group using traditional 3d bowel preparation,joint probiotic group,to give patients in the 1 d intestinal ready on the basis of probiotic oral.The two groups after patients received isonitrogenous and caloric nutritional support,were observed after the two groups of patients with body temperature and heart rate changes; detection of bacterial DNA ratio of whole blood.Observed in peripheral blood leukocyte count,and systemic inflammatory response syndrome(SIRS) and the occurrence of complications.Results Probiotic group and control group,postoperative fever duration and postoperative heart rate and leukocyte counts return to normal a short time( t =11.52,20.07,P ＜ 0.05 ) ; whole blood PCR detection of bacterial DNA after the positive test group 2 cases (3.30％),the control group was 8 cases ( 26.67％ ),the difference was statistically significant ( t =5.07,x2 =34.68,P ＜ 0.05 ).Postoperative SIRS rate and the incidence of complications showed no statistical difference ( P ＞ 0.05 ).Conclusion Probiotics could reduce colorectal cancer patients with postoperative intestinal permeability and reduce the incidence of bacterial translocation and its rapid intestinal preparation method was feasible and effective and knot the protection of the intestinal mucosal barrier function in rectal cancerconductive to knot the early postoperative inflammatory response in patients with rectal cancer recovery.
