中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
4期
330-332
,共3页
崔立谦%蒋莉君%邓伟%黄朝华%陈壮飞%李名立%王强%王英成%马小红%龚启勇%李涛
崔立謙%蔣莉君%鄧偉%黃朝華%陳壯飛%李名立%王彊%王英成%馬小紅%龔啟勇%李濤
최립겸%장리군%산위%황조화%진장비%리명립%왕강%왕영성%마소홍%공계용%리도
双相障碍%额叶%海马%磁共振波谱学
雙相障礙%額葉%海馬%磁共振波譜學
쌍상장애%액협%해마%자공진파보학
Bipolar disorder%Frontal lobe%Hippocampus%Magnetic resonance spectroscopy
目的 探讨双相Ⅰ型躁狂患者额叶白质、海马的磁共振质子波谱(1 H-MRS)变化特点.方法 对符合美国精神障碍诊断与统计手册第4版( DSM-Ⅳ)诊断标准的18例男性双相Ⅰ型躁狂发作患者和27名正常对照进行氢质子波谱扫描,检测双侧额叶白质和海马的N-乙酰天门冬氨酸(NAA)、胆碱(Cho)和肌酸(Cr),以Cr为参照物,分别计算双侧NAA/Cr、Cho/Cr比值.结果 双相Ⅰ型躁狂组左侧额叶白质、左侧海马NAA/Cr比正常对照组降低[(1.68±0.19,1.86 ±0.19),(1.32±0.10,1.43±0.16)],差异有统计学意义(t=2.99,2.62,P＜0.01),右侧额叶白质、海马NAA/Cr和双侧额叶白质、海马Cho/Cr与正常对照相比差异无统计学意义(t=0.29～ 1.59,P＞0.05).结论 男性双相Ⅰ型躁狂患者存在左侧额叶白质纤维和海马神经元的功能障碍.
目的 探討雙相Ⅰ型躁狂患者額葉白質、海馬的磁共振質子波譜(1 H-MRS)變化特點.方法 對符閤美國精神障礙診斷與統計手冊第4版( DSM-Ⅳ)診斷標準的18例男性雙相Ⅰ型躁狂髮作患者和27名正常對照進行氫質子波譜掃描,檢測雙側額葉白質和海馬的N-乙酰天門鼕氨痠(NAA)、膽堿(Cho)和肌痠(Cr),以Cr為參照物,分彆計算雙側NAA/Cr、Cho/Cr比值.結果 雙相Ⅰ型躁狂組左側額葉白質、左側海馬NAA/Cr比正常對照組降低[(1.68±0.19,1.86 ±0.19),(1.32±0.10,1.43±0.16)],差異有統計學意義(t=2.99,2.62,P＜0.01),右側額葉白質、海馬NAA/Cr和雙側額葉白質、海馬Cho/Cr與正常對照相比差異無統計學意義(t=0.29～ 1.59,P＞0.05).結論 男性雙相Ⅰ型躁狂患者存在左側額葉白質纖維和海馬神經元的功能障礙.
목적 탐토쌍상Ⅰ형조광환자액협백질、해마적자공진질자파보(1 H-MRS)변화특점.방법 대부합미국정신장애진단여통계수책제4판( DSM-Ⅳ)진단표준적18례남성쌍상Ⅰ형조광발작환자화27명정상대조진행경질자파보소묘,검측쌍측액협백질화해마적N-을선천문동안산(NAA)、담감(Cho)화기산(Cr),이Cr위삼조물,분별계산쌍측NAA/Cr、Cho/Cr비치.결과 쌍상Ⅰ형조광조좌측액협백질、좌측해마NAA/Cr비정상대조조강저[(1.68±0.19,1.86 ±0.19),(1.32±0.10,1.43±0.16)],차이유통계학의의(t=2.99,2.62,P＜0.01),우측액협백질、해마NAA/Cr화쌍측액협백질、해마Cho/Cr여정상대조상비차이무통계학의의(t=0.29～ 1.59,P＞0.05).결론 남성쌍상Ⅰ형조광환자존재좌측액협백질섬유화해마신경원적공능장애.
Objective To identify the metabolic alterations on prefrontal lobes and hippocampus in male patients with the first-episode mania using proton magnetic resonance spectroscopy(H-MRS).Method 18 male patients with the first-episode mania and 27 healthy subjects matched for age,gender,and years of education were included in the study.1 H-MRS was performed in two sides of the hippocampus and frontal lobes regions.The ratios of N-acetylaspartate (NAA),choline (Cho) to creatine (Cr) were measured.One-sample t test and paired-samples t test were used for statistic process.Results Male patients with the first-episode mania presented decreased NAA/Cr in left frontal lobe and hippocampus regions when compared to normal controls( left frontal lobe (1.68 ±0.19 vs 1.86 ± 0.19),hippocampus ( 1.32 ± 0.10 vs 1.43 ± 0.16 ),P ＜ 0.01 ),but there were no significant difference in NAA/Cr for right frontal lobe and hippocampus regions between groups ( all P ＞ 0.05 ).Two groups also showcd no significant difference for Cho/Cr in bilateral frontal lobe and hippocampus (P ＞ 0.05 ).Conclusion There is significant difference of manifestation of 1H-MRS between male patients with mania and normal controls,which reflects neuronal dysfunction in the prefrontal lobes and hippocampus.
