CAJ | 학술논문

目的对视网膜自适应光学成像系统所得视锥细胞图像进行处理,获取正常人眼底不同区域视锥细胞密度,探讨自适应光学成像系统用于眼科临床实验研究的可行性.方法横断面研究.利用自适应光学成像系统采集30例正常受试者不同区域视锥细胞图像,对图像进行处理获得正常人眼视网膜不同区域的视锥细胞密度,并采用回归分析法对不同区域的密度进行曲线估计.结果随测量点与黄斑中心凹的距离增加,视锥细胞密度呈现出降低的趋势.偏离黄斑中心凹0.5°到3°范围内,随着偏离度的增加,视锥细胞密度从70 000个/mm2下降到16 000个/mm2.结论自适应光学成像系统能够在活体人眼获取清晰的高分辨率视网膜图像,可能可以在眼科临床实验研究中发挥一定的作用.
목적 대시망막자괄응광학성상계통소득시추세포도상진행처리,획취정상인안저불동구역시추세포밀도,탐토자괄응광학성상계통용우안과림상실험연구적가행성.방법 횡단면연구.이용자괄응광학성상계통채집30례정상수시자불동구역시추세포도상,대도상진행처리획득정상인안시망막불동구역적시추세포밀도,병채용회귀분석법대불동구역적밀도진행곡선고계.결과 수측량점여황반중심요적거리증가,시추세포밀도정현출강저적추세.편리황반중심요0.5°도3°범위내,수착편리도적증가,시추세포밀도종70 000개/mm2하강도16 000개/mm2.결론 자괄응광학성상계통능구재활체인안획취청석적고분변솔시망막도상,가능가이재안과림상실험연구중발휘일정적작용.
Objective To study a practical application in clinical ophthalmology studies by measuring cone photoreceptor density from processed images obtained with an adaptive optics imaging system.Methods This was a cross-sectional study.An adaptive optics imaging system was used to image the cones of 30 normal human eyes and the position of each cone within the sampling windows was manually digitized by the investigator.From these cone counts,the density of the cones was calculated for a set of fixed distances from the fovea at locations throughout the image,and the images were processed to obtain the cone photoreceptor density in different regions (nasal and temporal sides, superior and inferior sides).A regression analysis was used to estimate the cone photoreceptor density in different regions. Results Cone photoreceptor densities decreased from 70 000 cells/mm2 to 16 000 cells/mm2 from a retinal eccentricity of 0.5°to 3°.Overall, cell densities showed a tendency to decrease with deviation from the fovea. Conclusion Clear high-resolution retinal images from human eyes in vivo can be obtained with an adaptive optics imaging system.This system may play a role in ophthalmology based clinical trials.