四川医学
四川醫學
사천의학
SICHUAN MEDICAL JOURNAL
2009年
7期
1035-1037
,共3页
慢性充血性心力衰竭%促炎性细胞因子%心肌纤维化%贝那普利%相关性研究
慢性充血性心力衰竭%促炎性細胞因子%心肌纖維化%貝那普利%相關性研究
만성충혈성심력쇠갈%촉염성세포인자%심기섬유화%패나보리%상관성연구
chronic heart failure%serum cytokine levels%myocardial fibrosi%benazepril%related research
目的 分析慢性充血性心力衰竭(CHF)患者血清促炎性细胞因子(IL-6、TNF-α)和心肌纤维化指标(PCⅢ、HA、LN)及其与心功能分级的关系;探讨血管紧张素转换酶抑制剂(ACEI)对CHF患者促炎性细胞因子和心肌纤维化水平调控作用.方法 采用放射免疫平衡法和流式细胞仪的液相蛋白定量技术检测113例CHF患者及正常对照组38例血清促炎性细胞因子(IL-6、TNF-α)和心肌纤维化指标(PCⅢI、HA、LN)浓度,并作相关性分析.结果 CHF组血清促炎性细胞因子(IL-6、TNF-α)和心肌纤维化指标(PCⅢ、LN、HA)显著高于正常对照组(P<0.05),且随着心功能的恶化而逐渐升高,血清促炎性细胞因子和心肌纤维化指标在不同心功能分级间(心功能Ⅱ、Ⅲ、Ⅳ级)比较均有显著性差异(P<0.05);血清促炎性细胞因子和心肌纤维化指标之间、心功能分级与血清促炎性细胞因子和心肌纤维化指标之间呈显著正相关;ACEI治疗组患者血清促炎性细胞因子和心肌纤维化指标水平较常规治疗组降低更明显,两组治疗后与治疗前比较、ACEI治疗组与常规治疗组比较差异均有统计学意义(P<0.05).结论 促炎性细胞因子的上调及心肌纤维化的程度与CHF的发生、发展、转归之间存在着一定的关联,与心衰严重程度密切相关;ACEI对CHF患者促炎性细胞因子和心肌纤维化水平具有调控作用.
目的 分析慢性充血性心力衰竭(CHF)患者血清促炎性細胞因子(IL-6、TNF-α)和心肌纖維化指標(PCⅢ、HA、LN)及其與心功能分級的關繫;探討血管緊張素轉換酶抑製劑(ACEI)對CHF患者促炎性細胞因子和心肌纖維化水平調控作用.方法 採用放射免疫平衡法和流式細胞儀的液相蛋白定量技術檢測113例CHF患者及正常對照組38例血清促炎性細胞因子(IL-6、TNF-α)和心肌纖維化指標(PCⅢI、HA、LN)濃度,併作相關性分析.結果 CHF組血清促炎性細胞因子(IL-6、TNF-α)和心肌纖維化指標(PCⅢ、LN、HA)顯著高于正常對照組(P<0.05),且隨著心功能的噁化而逐漸升高,血清促炎性細胞因子和心肌纖維化指標在不同心功能分級間(心功能Ⅱ、Ⅲ、Ⅳ級)比較均有顯著性差異(P<0.05);血清促炎性細胞因子和心肌纖維化指標之間、心功能分級與血清促炎性細胞因子和心肌纖維化指標之間呈顯著正相關;ACEI治療組患者血清促炎性細胞因子和心肌纖維化指標水平較常規治療組降低更明顯,兩組治療後與治療前比較、ACEI治療組與常規治療組比較差異均有統計學意義(P<0.05).結論 促炎性細胞因子的上調及心肌纖維化的程度與CHF的髮生、髮展、轉歸之間存在著一定的關聯,與心衰嚴重程度密切相關;ACEI對CHF患者促炎性細胞因子和心肌纖維化水平具有調控作用.
목적 분석만성충혈성심력쇠갈(CHF)환자혈청촉염성세포인자(IL-6、TNF-α)화심기섬유화지표(PCⅢ、HA、LN)급기여심공능분급적관계;탐토혈관긴장소전환매억제제(ACEI)대CHF환자촉염성세포인자화심기섬유화수평조공작용.방법 채용방사면역평형법화류식세포의적액상단백정량기술검측113례CHF환자급정상대조조38례혈청촉염성세포인자(IL-6、TNF-α)화심기섬유화지표(PCⅢI、HA、LN)농도,병작상관성분석.결과 CHF조혈청촉염성세포인자(IL-6、TNF-α)화심기섬유화지표(PCⅢ、LN、HA)현저고우정상대조조(P<0.05),차수착심공능적악화이축점승고,혈청촉염성세포인자화심기섬유화지표재불동심공능분급간(심공능Ⅱ、Ⅲ、Ⅳ급)비교균유현저성차이(P<0.05);혈청촉염성세포인자화심기섬유화지표지간、심공능분급여혈청촉염성세포인자화심기섬유화지표지간정현저정상관;ACEI치료조환자혈청촉염성세포인자화심기섬유화지표수평교상규치료조강저경명현,량조치료후여치료전비교、ACEI치료조여상규치료조비교차이균유통계학의의(P<0.05).결론 촉염성세포인자적상조급심기섬유화적정도여CHF적발생、발전、전귀지간존재착일정적관련,여심쇠엄중정도밀절상관;ACEI대CHF환자촉염성세포인자화심기섬유화수평구유조공작용.
Objective To investigate the relationship of serum cytokine levels (IL-6, TNF-α) and myocardial fibrosis (PCⅢ, HA, LN) with cardiac function in patients with chronic heart failure (CHF). Methods Serum concentrations of cyto-kinelevels (IL-6, TNF-α) and serum myocardial fibrosis (PCⅢ, HA, LN) in 113 cases with CHF patients and 38 cases nor-malcontrol group were measured using radioimmunoassay balance method and CBABD-pharmingen Cytometric Bead Array (CBA), and for correlation analysis. Results CHF serum cytokines ( IL-6, TNF-α) and myocardial fibrosis index ( PC Ⅲ, LN, HA) was significandy higher than the normal control group (P<0.05), and with the deterioration of cardiac function gradu-ally ncreased, serum cytokines and myocardial fibrosis in different indicators of cardiac function between the (cardiac functiong-rade Ⅱ ,Ⅲ,Ⅳ level) compared were significantly different (P<0.05) ; Serum cytokines and myocardial fibrosist indicators, cardiac function and serum cytokines and myocardial fibrosis indicators were significantly correlated; ACEI treatment group serum cytokine levels and myocardial fibrosis index lower than the conventional treatment group, mot～ obviously, the two groups after treatment compared with before treatment, ACEI treatment group compared with the conventional treatment group were significant-ly different (P<0.05). Conclusion Cytokineimbalance and the extent of myocardial fibrosis and the CHF occurrence, devel-opment, and the vesting have a certain relevance, and are related to the severity of heart failure; ACEI has a regulating role for cytokine levels and myocardial fibrosis in patients with CHF.
