CAJ | 학술논문

患者,男,33岁,发现腰部肿物2个月,行肿物切除病理提示为非霍奇金淋巴瘤,T细胞,免疫母细胞,血象大致正常,骨髓可见2%肉瘤细胞,诊断:非霍奇金淋巴瘤T细胞,Ⅳ期.予CHOP(环磷酰胺、阿霉素、长春新碱、强的松)等方案化疗4个月后,于1998-04行激活骨髓加自体外周血干细胞移植并联用重组白细胞介素2治疗.预处理方案为MACC方案(马法兰、阿糖胞苷,环磷酰胺,环己亚硝脲),移植+10 d,中性粒细胞>0.5×109L-1,移植+16 d,血小板>50×109L-1.移植+6 d出现发热,血培养为大肠埃希秆菌,经抗生素治疗体温正常,症状消失.随访至今已10年10个月,仍无病生存,工作及生活正常.
환자,남,33세,발현요부종물2개월,행종물절제병리제시위비곽기금림파류,T세포,면역모세포,혈상대치정상,골수가견2%육류세포,진단:비곽기금림파류T세포,Ⅳ기.여CHOP(배린선알、아매소、장춘신감、강적송)등방안화료4개월후,우1998-04행격활골수가자체외주혈간세포이식병련용중조백세포개소2치료.예처리방안위MACC방안(마법란、아당포감,배린선알,배기아초뇨),이식+10 d,중성립세포>0.5×109L-1,이식+16 d,혈소판>50×109L-1.이식+6 d출현발열,혈배양위대장애희간균,경항생소치료체온정상,증상소실.수방지금이10년10개월,잉무병생존,공작급생활정상.
A 33-year-old male patient complained of presenting goiter on the low back area for 2 months. Pathological examinations of resected goiter suggested non-Hodgkin lymphoma and showed that T cells, immunoblasts, and hemogram were roughly normal, and 2% sarcoma cells could be found in bone marrow. Stage Ⅳ T-cell non-Hodgkin's lymphoma was diagnosed. Following 4 months of chemotherapy using CHOP protocol (cyclophosphamide, adriamycin, vincristine, and prednisone included), the patient underwent bone marrow activation and autologous peripheral blood stem cell transplantation in combination with recombinant interleukin-2 application in April 1998. The preprocessing was performed under MACC protocol (L-sarcolysinum, cytarabine, cyclophosphamide, and Iomustine included). Ten days after autologous stem cell transplantation, neutrophil concentration was > 0.5×109/L and sixteen days after transplantation, blood platelet concentration was > 50×109/L. Six days after transplantation, the patient exhibited fever, and E. Coli infection was confirmed through blood culture. After antibiotic treatment, body temperature recovered to normal, and fever disappeared. The patient had been followed-up for 10 years and 10 months. During the follow-up period, he lived a normal life and work.