CAJ | 학술논문

目的:检测突发性耳聋(sudden hearing loss,SHL)患者血清抗内皮细胞抗体(anti-endothelial cell antibody,AECA)的水平并探讨其临床价值.方法:采用酶联免疫吸附方法检测67例SHL患者(SHL组)及30例健康者(对照组)的血清AECA水平.分析血清AECA与SHL患者性别、年龄、听力损失程度、听力下降类型及预后之间的关系.结果:AECA阳性率在SHL组、对照组中分别为70.15%(47/67)、23.33%(7/30),差异有统计学意义( P=0.0000).SHL组血清AECA浓度显著高于对照组(P=0.0001).血清AECA阳性分布与患者性别、年龄、听力下降类型无显著相关,但与听力下降程度和预后呈显著相关(P=0.0366;P=0.0324);且在41.031 ng/mL~162.26 ng/mL范围内时,AECA水平与患者预后呈正相关(r=0.7346,P=0.0000).对照组和SHL组ROC曲线下面积为0.7657[标准误为0.0479,95%可信区间为(0.66830~0.85594)].结论:血清中的AECA可能在SHL的发病机制中发挥了重要作用,AECA还有望作为患者筛选及指导预后的血清学指标.
목적:검측돌발성이롱(sudden hearing loss,SHL)환자혈청항내피세포항체(anti-endothelial cell antibody,AECA)적수평병탐토기림상개치.방법:채용매련면역흡부방법검측67례SHL환자(SHL조)급30례건강자(대조조)적혈청AECA수평.분석혈청AECA여SHL환자성별、년령、은력손실정도、은력하강류형급예후지간적관계.결과:AECA양성솔재SHL조、대조조중분별위70.15%(47/67)、23.33%(7/30),차이유통계학의의( P=0.0000).SHL조혈청AECA농도현저고우대조조(P=0.0001).혈청AECA양성분포여환자성별、년령、은력하강류형무현저상관,단여은력하강정도화예후정현저상관(P=0.0366;P=0.0324);차재41.031 ng/mL~162.26 ng/mL범위내시,AECA수평여환자예후정정상관(r=0.7346,P=0.0000).대조조화SHL조ROC곡선하면적위0.7657[표준오위0.0479,95%가신구간위(0.66830~0.85594)].결론:혈청중적AECA가능재SHL적발병궤제중발휘료중요작용,AECA환유망작위환자사선급지도예후적혈청학지표.