CAJ | 학술논문

弥漫性泛细支气管炎(diffuse panbronchiolitis,DPB)患者的呼吸性细支气管区域有淋巴细胞、浆细胞、巨噬细胞浸润和聚集,支气管组织中的树突细胞异常以及支气管肺泡灌洗液CD4+/CD8+细胞比值增高.血冷凝集试验效价持续升高.IgA增高等提示DPB的发病可能与免疫功能紊乱有关.
미만성범세지기관염(diffuse panbronchiolitis,DPB)환자적호흡성세지기관구역유림파세포、장세포、거서세포침윤화취집,지기관조직중적수돌세포이상이급지기관폐포관세액CD4+/CD8+세포비치증고.혈냉응집시험효개지속승고.IgA증고등제시DPB적발병가능여면역공능문란유관.
Diffuse panbronchiolitis (DPB) is characterized by chronic inflammation, predominantlylocalized in the bronchile and respiratory bronchioles, with infiltration of lymphocytes plasma cells andhistiocytes,and dendritic cells (DCs) is found abnormality in the bronchus tissue. Also DCs in theperibronchial tissue are abnormal and the ratio of CD4+/CD8+ in the bronchoalveolar lavage is high, togetherwith the character elevation of cold agglutinin titer and the increase of IgA in DPB. All of these show thatthere is abnormality in the patients' immunity system.