中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
16期
12-14
,共3页
张佳宾%阳书坤%余勤%岳红梅%汪小亚
張佳賓%暘書坤%餘勤%嶽紅梅%汪小亞
장가빈%양서곤%여근%악홍매%왕소아
C反应蛋白质%睡眠呼吸暂停,阻塞性%抑郁%相关性
C反應蛋白質%睡眠呼吸暫停,阻塞性%抑鬱%相關性
C반응단백질%수면호흡잠정,조새성%억욱%상관성
C-reactive protein%Sleep apnea,obstructive%Depression%Correlation
目的 探讨阻塞型睡眠呼吸暂停低通气综合征(OSAHS)患者抑郁情绪和高敏C反应蛋白(hs-CRP)的改变及相关关系.方法 选择OSAHS患者54例(OSAHS组)和健康对照者30例(对照组),使用抑郁自评量表(SDS)和采用速率散射比浊法分别评估受试者的抑郁情绪状态和测定其血清hs-CRP水平.结果 OSAHS组患者SDS评分和hs-CRP水平分别为(48.8±12.7)分、(3.3±0.7)mg/L,均高于对照组的(36.3±6.3)分、(1.4±0.4)mg/L(P＜0.01).SDS评分和hs-CRP水平与睡眠呼吸暂停低通气指数(AHI)呈正相关(r=0.636、0.628,P<0.01);与平均血氧饱和度(MSa02)(r=-0.509、-0.614,P<001)、最低血氧饱和度(LSaO-2)(r=-0.607、-0.512,P<0.01)呈负相关;SDS评分与hs-CRP水平呈正相关(r=0.536,p<0.01).SDS评分与AHI、hs-CRP和LSaO2呈直线回归关系(F=33.31,P:0,002).结论 OSAHS患者存在抑郁情绪障碍和hs-CRP水平增高,且与OSAHS病情程度相关;血清hs-CRP水平增高是OSAHS抑郁障碍高发的原因之一.
目的 探討阻塞型睡眠呼吸暫停低通氣綜閤徵(OSAHS)患者抑鬱情緒和高敏C反應蛋白(hs-CRP)的改變及相關關繫.方法 選擇OSAHS患者54例(OSAHS組)和健康對照者30例(對照組),使用抑鬱自評量錶(SDS)和採用速率散射比濁法分彆評估受試者的抑鬱情緒狀態和測定其血清hs-CRP水平.結果 OSAHS組患者SDS評分和hs-CRP水平分彆為(48.8±12.7)分、(3.3±0.7)mg/L,均高于對照組的(36.3±6.3)分、(1.4±0.4)mg/L(P＜0.01).SDS評分和hs-CRP水平與睡眠呼吸暫停低通氣指數(AHI)呈正相關(r=0.636、0.628,P<0.01);與平均血氧飽和度(MSa02)(r=-0.509、-0.614,P<001)、最低血氧飽和度(LSaO-2)(r=-0.607、-0.512,P<0.01)呈負相關;SDS評分與hs-CRP水平呈正相關(r=0.536,p<0.01).SDS評分與AHI、hs-CRP和LSaO2呈直線迴歸關繫(F=33.31,P:0,002).結論 OSAHS患者存在抑鬱情緒障礙和hs-CRP水平增高,且與OSAHS病情程度相關;血清hs-CRP水平增高是OSAHS抑鬱障礙高髮的原因之一.
목적 탐토조새형수면호흡잠정저통기종합정(OSAHS)환자억욱정서화고민C반응단백(hs-CRP)적개변급상관관계.방법 선택OSAHS환자54례(OSAHS조)화건강대조자30례(대조조),사용억욱자평량표(SDS)화채용속솔산사비탁법분별평고수시자적억욱정서상태화측정기혈청hs-CRP수평.결과 OSAHS조환자SDS평분화hs-CRP수평분별위(48.8±12.7)분、(3.3±0.7)mg/L,균고우대조조적(36.3±6.3)분、(1.4±0.4)mg/L(P＜0.01).SDS평분화hs-CRP수평여수면호흡잠정저통기지수(AHI)정정상관(r=0.636、0.628,P<0.01);여평균혈양포화도(MSa02)(r=-0.509、-0.614,P<001)、최저혈양포화도(LSaO-2)(r=-0.607、-0.512,P<0.01)정부상관;SDS평분여hs-CRP수평정정상관(r=0.536,p<0.01).SDS평분여AHI、hs-CRP화LSaO2정직선회귀관계(F=33.31,P:0,002).결론 OSAHS환자존재억욱정서장애화hs-CRP수평증고,차여OSAHS병정정도상관;혈청hs-CRP수평증고시OSAHS억욱장애고발적원인지일.
Objective To study the changes of serum high-sensitivity C-reactive protein (ha-CRP) and depression in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS),and investigate the relationship between them.Methods Thirty healthy volunteers (control group) and 54 OSAHS patients (OSAHS group) were recruited for the study.The level of serum hs-CRP was determined by scatter rate nephelometry,and the state of depression was assessed by self-rating depression scale (SDS).Results The level of serum hs-CRP and SDS score were higher in OSAHS group than those in control group [(48.8 ± 12.7) scores vs.(36.3 ± 6.3) scores,(3.3 ±0.7) mg/L vs.(1.4 ± 0.4) mg/L](P＜0.01).SDS score and the level of serum hs-CRPwere positively correlated to apnea-hypopnea index(AHI) (r = 0.636,0.628 ;P<0.01) and negatively related to the MSaO2 (r =-0.509,-0.614;P <0.01) and LSaO2 (r =-0.607,-0.512;P <0.01).The level of serum hs-CRP was positive correlation to SDS score (r = 0.536,P<0.01).SDS score was related to the AHI,the level of serum hs-CRP and LSaO2 in multiple linear regression(F= 33.31,P = 0.002).Conclusion Depression is correlated to AHI and the level of serum hs-CRP in patients with OSAHS.
