中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2010年
9期
1171-1173
,共3页
抗原,CD147/代谢%NF-κB/代谢%食管肿瘤/代谢%癌,鳞状细胞/代谢
抗原,CD147/代謝%NF-κB/代謝%食管腫瘤/代謝%癌,鱗狀細胞/代謝
항원,CD147/대사%NF-κB/대사%식관종류/대사%암,린상세포/대사
Antigens,CD147/ME%NF-kappa B/ME%Esophageal neoplasms/ME%Carcinoma,squamous cell/ME
目的 研究基质金属蛋白酶刺激因子(CD147)、核转录因子-κB[NF-κB(p65)]在食管鳞状细胞癌组织中的表达及其在食管鳞癌侵袭转移的作用及可能机制.方法 应用免疫组织化学方法检测40例食管鳞癌患者癌组织及其癌旁正常对照组织CD147、NF-κB的表达.结果 CD147、NF-κB在食管鳞癌表达阳性率为77.5%、87.5%,在癌旁正常对照组为25%、42.5%,2组差异有统计学意义(P＜0.05);CD147在早期和中晚期食管癌表达阳性率为33.3%、90.3%,在NF-κB为55.6%、96.8%,2组差异均有统计学意义(P＜0.05);CD147在食管鳞癌无转移和转移组表达阳性率为28.6%、87.9%,在NF-κB为42.9%、97%,2组差异均有统计学意义(P＜0.05).结论 CD147、NF-κB在食管鳞癌组织表达增高,与肿瘤的浸润、转移相关,它们可能是通过共同的作用途径来实现的.
目的 研究基質金屬蛋白酶刺激因子(CD147)、覈轉錄因子-κB[NF-κB(p65)]在食管鱗狀細胞癌組織中的錶達及其在食管鱗癌侵襲轉移的作用及可能機製.方法 應用免疫組織化學方法檢測40例食管鱗癌患者癌組織及其癌徬正常對照組織CD147、NF-κB的錶達.結果 CD147、NF-κB在食管鱗癌錶達暘性率為77.5%、87.5%,在癌徬正常對照組為25%、42.5%,2組差異有統計學意義(P＜0.05);CD147在早期和中晚期食管癌錶達暘性率為33.3%、90.3%,在NF-κB為55.6%、96.8%,2組差異均有統計學意義(P＜0.05);CD147在食管鱗癌無轉移和轉移組錶達暘性率為28.6%、87.9%,在NF-κB為42.9%、97%,2組差異均有統計學意義(P＜0.05).結論 CD147、NF-κB在食管鱗癌組織錶達增高,與腫瘤的浸潤、轉移相關,它們可能是通過共同的作用途徑來實現的.
목적 연구기질금속단백매자격인자(CD147)、핵전록인자-κB[NF-κB(p65)]재식관린상세포암조직중적표체급기재식관린암침습전이적작용급가능궤제.방법 응용면역조직화학방법검측40례식관린암환자암조직급기암방정상대조조직CD147、NF-κB적표체.결과 CD147、NF-κB재식관린암표체양성솔위77.5%、87.5%,재암방정상대조조위25%、42.5%,2조차이유통계학의의(P＜0.05);CD147재조기화중만기식관암표체양성솔위33.3%、90.3%,재NF-κB위55.6%、96.8%,2조차이균유통계학의의(P＜0.05);CD147재식관린암무전이화전이조표체양성솔위28.6%、87.9%,재NF-κB위42.9%、97%,2조차이균유통계학의의(P＜0.05).결론 CD147、NF-κB재식관린암조직표체증고,여종류적침윤、전이상관,타문가능시통과공동적작용도경래실현적.
Objective To investigate the expression of extracellular matrix metalloproteinase inducer (CD147), nuclear factor kappa B (NF-κB) in esophageal squamous cell carcinoma tissue and probe their relationship to invasion and metastasis of esophageal carcinoma. Methods Immunochemical staining was performed to detect the expression of CD147 and NF-κB protein in 40 cases of esophageal carcinoma tissues and 40 cases of normal control. Results The positive rate of CD147 and NF-κB in esophageal carcinoma tissues and in adjacent noncancerous tissues were 77.5%/87.5% Vs 25%/42. 5%, P＜0.05.The positive rate of their prophase and metaphase-advanced stage esophageal carcinoma tissues were 33.3%/90.3% Vs 55.6%/96.8%, P＜0.05..The positive rate of non-metastatic and metastatic esophageal carcinoma tissues were 28.6%/87.9% Vs 42.9%/97%, P＜0.05.Conclusions Our results suggested that the increased expression of CD147 and NF-κB contributed to tumor angiogenesis in esophageal squamous cell carcinoma, which might be through the common pathway.
