CAJ | 학술논문

目的探讨突发性耳聋患者血清脂联素和血清高敏C-反应蛋白(Hs-CRP)的含量变化,及其在突发性耳聋发生过程中的作用和意义.方法采用酶联免疫(ELISA)法检测血清脂联素含量,采用免疫比浊法对血清Hs-CRP进行测定;检测102例突发性耳聋患者、35例其他疾病对照组和30例正常健康对照组的血清脂联素和Hs-CRP含量,并比较治疗前后血清脂联素和Hs-CRP的测定结果 .结果突发性耳聋患者治疗前血清Hs-CRP含量较两对照组显著升高(P<0.01);治疗后恢复组患者Hs-CRP含量明显降低.突发性耳聋患者治疗前血清脂联素含量较两对照组显著降低(P<0.01);治疗后恢复组患者脂联素含量明显升高.突发性耳聋患者血清脂联素和Hs-CRP含量之间呈负相关(r=-0.63,P<0.01).结论血清脂联素和Hs-CRP水平的变化与突发性耳聋病情严重程度密切相关.
목적 탐토돌발성이롱환자혈청지련소화혈청고민C-반응단백(Hs-CRP)적함량변화,급기재돌발성이롱발생과정중적작용화의의.방법 채용매련면역(ELISA)법검측혈청지련소함량,채용면역비탁법대혈청Hs-CRP진행측정;검측102례돌발성이롱환자、35례기타질병대조조화30례정상건강대조조적혈청지련소화Hs-CRP함량,병비교치료전후혈청지련소화Hs-CRP적측정결과 .결과 돌발성이롱환자치료전혈청Hs-CRP함량교량대조조현저승고(P<0.01);치료후회복조환자Hs-CRP함량명현강저.돌발성이롱환자치료전혈청지련소함량교량대조조현저강저(P<0.01);치료후회복조환자지련소함량명현승고.돌발성이롱환자혈청지련소화Hs-CRP함량지간정부상관(r=-0.63,P<0.01).결론 혈청지련소화Hs-CRP수평적변화여돌발성이롱병정엄중정도밀절상관.
Objective To study the role and clinical significance of serum adiponectin and high-sensitivity C-reative protein(Hs-CRP)in idiopathic sudden sensorineural hearing loss by measuring the change of their levels in the patients with idiopathic sudden sensorineural hearing loss.Methods Adiponectin Was determined by ELISA method,Hs-CBP was determined by rate nephelometry immunoassuy.The levels adiponectin and Hs-CRP were determined in the 102 idiopathic sudden sensorineural hearing loss patients who were observed at two different time points:before and after treatment,and thirty-five patients with other neurologic diseases(20with sciatica,16withtrigeminal neuralgia)and thirty healthy people were used as control.Results The levels of Hs-CRP in serum of patients with idiopathic sudden sensorineural hearing loss were markedly higher than those in the two control groups(P<0.01);the levels of Hs-CRP in the idiopathic sudden sensorineural hearing loss group after treatment were significantly less than that before treatment(P<0.01).The levels adiponectin in serum of pailents with idiopathic sudden sensorineural hearing loss were markedly lower than those in the two control groups(P<0.01);the levels of adiponectin in the idiopathic sudden sensorineural hearing loss group after treatment were significantly higher than that before treatment(P<0.01).There was negatively correlation between adiponectin and Hs-CRP in patients with idiopathic sudden sensorineural hearing loss(r=-0.63,P<0.01).Conclusion The levels of serum adiponectin and Hs-CRP have instructive significance in idiopathic sudden sensorineural hearing loss treating and prognosis estimating.