中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
3期
309-310
,共2页
胰腺炎%围术期%白细胞介素6%白细胞介素8%肿瘤坏死因子类%C反应蛋白质
胰腺炎%圍術期%白細胞介素6%白細胞介素8%腫瘤壞死因子類%C反應蛋白質
이선염%위술기%백세포개소6%백세포개소8%종류배사인자류%C반응단백질
Pancreatitis%Perioperative%IL-6%IL-8%TNF-α%CRP
目的 探讨胰腺炎患者围术期血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子(TNF)-α及C反应蛋白(CRP)水平变化情况及临床意义.方法 选取手术治疗的胰腺炎患者39例为研究对象(观察组),选取同期健康体检正常者39名为对照组,检测两组血清IL-6、IL-8、TNF-α及CRP水平,并分析观察组术后4 h、术后1 d、2 d及7 d各项观察指标变化情况.结果 观察组术前血清IL-6[(89.87±6.52)ng/L]、IL-8[(99.76±5.74)ng/L]、TNF-α[(40.56±3.67)ng/L]及CRP[(49.82±2.85)mg/L]水平均明显高于对照组(t=7.25、7.87、5.32、6.28,均P＜0.01),而术后4 h、1d及2 d各项指标有所下降,但与对照组比较,差异均有统计学意义(均P＜0.05);至术后7 d,两组各项指标比较,差异均无统计学意义(均P＞0.05).结论 胰腺炎患者术前血清IL-6、IL-8、TNF-α及CRP水平明显增高,至术后7 d恢复正常.
目的 探討胰腺炎患者圍術期血清白細胞介素-6(IL-6)、白細胞介素-8(IL-8)、腫瘤壞死因子(TNF)-α及C反應蛋白(CRP)水平變化情況及臨床意義.方法 選取手術治療的胰腺炎患者39例為研究對象(觀察組),選取同期健康體檢正常者39名為對照組,檢測兩組血清IL-6、IL-8、TNF-α及CRP水平,併分析觀察組術後4 h、術後1 d、2 d及7 d各項觀察指標變化情況.結果 觀察組術前血清IL-6[(89.87±6.52)ng/L]、IL-8[(99.76±5.74)ng/L]、TNF-α[(40.56±3.67)ng/L]及CRP[(49.82±2.85)mg/L]水平均明顯高于對照組(t=7.25、7.87、5.32、6.28,均P＜0.01),而術後4 h、1d及2 d各項指標有所下降,但與對照組比較,差異均有統計學意義(均P＜0.05);至術後7 d,兩組各項指標比較,差異均無統計學意義(均P＞0.05).結論 胰腺炎患者術前血清IL-6、IL-8、TNF-α及CRP水平明顯增高,至術後7 d恢複正常.
목적 탐토이선염환자위술기혈청백세포개소-6(IL-6)、백세포개소-8(IL-8)、종류배사인자(TNF)-α급C반응단백(CRP)수평변화정황급림상의의.방법 선취수술치료적이선염환자39례위연구대상(관찰조),선취동기건강체검정상자39명위대조조,검측량조혈청IL-6、IL-8、TNF-α급CRP수평,병분석관찰조술후4 h、술후1 d、2 d급7 d각항관찰지표변화정황.결과 관찰조술전혈청IL-6[(89.87±6.52)ng/L]、IL-8[(99.76±5.74)ng/L]、TNF-α[(40.56±3.67)ng/L]급CRP[(49.82±2.85)mg/L]수평균명현고우대조조(t=7.25、7.87、5.32、6.28,균P＜0.01),이술후4 h、1d급2 d각항지표유소하강,단여대조조비교,차이균유통계학의의(균P＜0.05);지술후7 d,량조각항지표비교,차이균무통계학의의(균P＞0.05).결론 이선염환자술전혈청IL-6、IL-8、TNF-α급CRP수평명현증고,지술후7 d회복정상.
Objective To study the variation of serum IL-6,IL-8,TNF-α and CRP in perioperative patients with pancreatitis. Methods 39 caaes in perioperative patients with pancreatitis in our hospital from January 2008 to 2010 April were selected as observation group,and 39 healthy people were selected as control group,and the serum IL-6,IL-8,TNF-α and CRP of the observation group before the treatment and after the treatment at 4h,at the first day, at the second day and the seventh day and the control group were detected, and the results were analyzed and compared. Results The serum IL-6,IL-8 ,TNF-α and CRP of the observation group before the treatment were higher than those of the control group( all P ＜ 0. 01 ) there were significant differences, and the levels of the observation group at 4h,at the first day,and at the second day showed decreasing,the levels compared to those of the control group( all P ＜ 0. 05 ) there were significant differences, the levels of the observation group at seventh day were compared to those of the control group(all P＞0. 05) there were no significant differences. Conclusion It was regulation of the variation of serum IL-6, IL-8 ,TNF-α and CRP in perioperative patients with pancreatitis, and tit could provide evidence for the treatment.
