中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2009年
7期
715-718
,共4页
辛伐他汀%颈动脉粥样硬化%软斑块
辛伐他汀%頸動脈粥樣硬化%軟斑塊
신벌타정%경동맥죽양경화%연반괴
Simvastatin%Carotid atherosclerosis%Soft plaque
目的 通过辛伐他汀对颈动脉粥样硬化斑块中的软斑块的干预,观察其能否有效干预颈动脉粥样硬化斑块中软斑块的进展,从而达到防治脑血管疾病(CVD)的目的 .方法 将符合入选标准的300例患者随机分为治疗组和对照组,每组各150例.对照组采用氯吡格雷(75 mg/次,1次/d), 治疗组在氯吡格雷治疗的基础上加辛伐他汀(三精制药厂生产,20 mg/次,每晚1次),疗程均为6个月.两组患者治疗6个月后复查彩超,记录斑块性质、大小和数目等. 结果比较两组软斑块消退、软斑块数目减少、斑块稳定情况,治疗组显著优于对照组,差异有统计学意义(P<0.01).结论 辛伐他汀能逆转和稳定动脉粥样硬化斑块,从而减少脑血管事件的发生.
目的 通過辛伐他汀對頸動脈粥樣硬化斑塊中的軟斑塊的榦預,觀察其能否有效榦預頸動脈粥樣硬化斑塊中軟斑塊的進展,從而達到防治腦血管疾病(CVD)的目的 .方法 將符閤入選標準的300例患者隨機分為治療組和對照組,每組各150例.對照組採用氯吡格雷(75 mg/次,1次/d), 治療組在氯吡格雷治療的基礎上加辛伐他汀(三精製藥廠生產,20 mg/次,每晚1次),療程均為6箇月.兩組患者治療6箇月後複查綵超,記錄斑塊性質、大小和數目等. 結果比較兩組軟斑塊消退、軟斑塊數目減少、斑塊穩定情況,治療組顯著優于對照組,差異有統計學意義(P<0.01).結論 辛伐他汀能逆轉和穩定動脈粥樣硬化斑塊,從而減少腦血管事件的髮生.
목적 통과신벌타정대경동맥죽양경화반괴중적연반괴적간예,관찰기능부유효간예경동맥죽양경화반괴중연반괴적진전,종이체도방치뇌혈관질병(CVD)적목적 .방법 장부합입선표준적300례환자수궤분위치료조화대조조,매조각150례.대조조채용록필격뢰(75 mg/차,1차/d), 치료조재록필격뢰치료적기출상가신벌타정(삼정제약엄생산,20 mg/차,매만1차),료정균위6개월.량조환자치료6개월후복사채초,기록반괴성질、대소화수목등. 결과비교량조연반괴소퇴、연반괴수목감소、반괴은정정황,치료조현저우우대조조,차이유통계학의의(P<0.01).결론 신벌타정능역전화은정동맥죽양경화반괴,종이감소뇌혈관사건적발생.
Objective To observe the effect of simvastatin on the soft plaque of carotid atherosclerosis.Methods Three hundred patients with carotid atherosclerosis were randomly divided into two groups and each group had 150 patients, respectively. The control group treated by clopidogrel(75mg qd) and the treatment group added simvastatin (20mg qn) besides clopidogrel. All patients rechecked by color doppler ultrasonography after 6 months'of treatment, then the variation of the carotid atherosclerosis in two group were compared.Results The soft plaque of carotid atherosclerosis in the treatment group had more incidence of extinction, decreasing or stabilization of soft plaque than control group.Conclusion Simvastatin can reverse and stabilize the belt plaque of carotid atherosclerosis.
