CAJ | 학술논문

随着医学影像学的发展,基于脑内血氧水平变化的功能磁共振成像(fMRI)技术逐渐成为研究人脑功能的最主要的手段之一,但它的时间分辨率低.近年提出的神经电流磁共振成像(nc-MRI)是一种利用磁共振成像(MRI)技术对神经活动产生的电磁场直接成像的新方法.在原理上,nc-MRI是一种无创伤且同时具有高时间和空间分辨率特性的技术.因此,它的出现有可能会极大地推进脑功能的研究.探讨了nc-MRI信号的产生机制,包括神经磁场的理论模型和nc-MRI信号源及nc-MRI信号的模拟计算,其中包括对树突分支磁场的模拟以及nc-MRI的实验研究进展:展望了nc-MRI的未来发展方向.
수착의학영상학적발전,기우뇌내혈양수평변화적공능자공진성상(fMRI)기술축점성위연구인뇌공능적최주요적수단지일,단타적시간분변솔저.근년제출적신경전류자공진성상(nc-MRI)시일충이용자공진성상(MRI)기술대신경활동산생적전자장직접성상적신방법.재원리상,nc-MRI시일충무창상차동시구유고시간화공간분변솔특성적기술.인차,타적출현유가능회겁대지추진뇌공능적연구.탐토료nc-MRI신호적산생궤제,포괄신경자장적이론모형화nc-MRI신호원급nc-MRI신호적모의계산,기중포괄대수돌분지자장적모의이급nc-MRI적실험연구진전:전망료nc-MRI적미래발전방향.
With the development of medical imaging technology, hemodynamics-based functional magnetic resonance imaging (fMRI) has gradually become one of the major tools to investigate human brain function, however, it is of limited temporal resolution. In recent years, neuronal current MRI (nc-MRI) was proposed as a new imaging method to directly map the magnetic field change caused by neural activities. Theoretically, nc-MRI can non-inva- sively locate brain activities with very high spatial and temporal resolution, thus it may greatly improve the study of human brain function. This paper reviews the construction mechanism of nc-MRI, including theoretical model of the neuronal magnetic field and signal source. Arithmetic simulation of nc-MRI signal with an illustration of our work on simulation of a dendrite branch magnetic field is presented. New development of the experimental studies and foreground of nc-MRI area are discussed.