中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2012年
1期
36-38
,共3页
蒋飞照%朱恒梁%郑晓风%屠金夫%林虹%胡如英%陈雄%尤和谊%周振旭%张维建%蔡华杰
蔣飛照%硃恆樑%鄭曉風%屠金伕%林虹%鬍如英%陳雄%尤和誼%週振旭%張維建%蔡華傑
장비조%주항량%정효풍%도금부%림홍%호여영%진웅%우화의%주진욱%장유건%채화걸
十二指肠空肠旁路术%2型糖尿病%非过度肥胖%血糖
十二指腸空腸徬路術%2型糖尿病%非過度肥胖%血糖
십이지장공장방로술%2형당뇨병%비과도비반%혈당
Duodenojejunal bypass%Type 2 diabetes mellitus%Non-severe obese%Blood glucose
目的 探讨十二指肠空肠旁路术(DJB)治疗非过度肥胖型2型糖尿病(T2DM)的疗效和可行性.方法 随访并检测7例行十二指肠空肠旁路术的非过度肥胖型T2DM患者术前和术后24周内的体质量指数(BMI)、空腹血糖(FPG)、餐后2h血糖(2hPG)、空腹胰岛素(F-ins)、空腹C肽(F-CP)和糖化血红蛋白(HbA1c),结合患者所应用的降糖药物剂量的变化,分析术后24周患者T2DM转归情况.结果 接受DJB的7例T2DM患者,1例完全脱离降糖药物,FBG、2hPG和HbA1c正常;5例应用降糖药物剂量明显减少,但尚未完全脱离药物；1例无明显改善.血糖完全缓解比例1/7,有效比例6/7,HbA1c达标比例5/7;患者术后各时间段BMI较术前均无明显变化.结论 十二指肠空肠旁路术可以降低非过度肥胖T2DM患者的血糖,其对血糖的控制不依赖于体质量的降低,机制尚未完全明确.
目的 探討十二指腸空腸徬路術(DJB)治療非過度肥胖型2型糖尿病(T2DM)的療效和可行性.方法 隨訪併檢測7例行十二指腸空腸徬路術的非過度肥胖型T2DM患者術前和術後24週內的體質量指數(BMI)、空腹血糖(FPG)、餐後2h血糖(2hPG)、空腹胰島素(F-ins)、空腹C肽(F-CP)和糖化血紅蛋白(HbA1c),結閤患者所應用的降糖藥物劑量的變化,分析術後24週患者T2DM轉歸情況.結果 接受DJB的7例T2DM患者,1例完全脫離降糖藥物,FBG、2hPG和HbA1c正常;5例應用降糖藥物劑量明顯減少,但尚未完全脫離藥物；1例無明顯改善.血糖完全緩解比例1/7,有效比例6/7,HbA1c達標比例5/7;患者術後各時間段BMI較術前均無明顯變化.結論 十二指腸空腸徬路術可以降低非過度肥胖T2DM患者的血糖,其對血糖的控製不依賴于體質量的降低,機製尚未完全明確.
목적 탐토십이지장공장방로술(DJB)치료비과도비반형2형당뇨병(T2DM)적료효화가행성.방법 수방병검측7례행십이지장공장방로술적비과도비반형T2DM환자술전화술후24주내적체질량지수(BMI)、공복혈당(FPG)、찬후2h혈당(2hPG)、공복이도소(F-ins)、공복C태(F-CP)화당화혈홍단백(HbA1c),결합환자소응용적강당약물제량적변화,분석술후24주환자T2DM전귀정황.결과 접수DJB적7례T2DM환자,1례완전탈리강당약물,FBG、2hPG화HbA1c정상;5례응용강당약물제량명현감소,단상미완전탈리약물；1례무명현개선.혈당완전완해비례1/7,유효비례6/7,HbA1c체표비례5/7;환자술후각시간단BMI교술전균무명현변화.결론 십이지장공장방로술가이강저비과도비반T2DM환자적혈당,기대혈당적공제불의뢰우체질량적강저,궤제상미완전명학.
Objective To investigate the efficacy and feasibility of duodenojejunal bypass(DJB) on non-severe obese patients with type 2 diabetes mellitus (T2DM). Methods The body mass index (BMI),fasting plasma glucose (FPG),2h-postprandial plasma glucose (2hPG),fasting insulin (F-ins),fasting c-peptide(F-CP),glycated hemoglobin and hypoglycemic agents dose changes were tested in 7 patients with non-severe obese T2DM undergoing DJB,preoperatively and within 24 weeks after surgery during the follow-up.Data were collected and the clinical outcomes of T2DM were analyzed.Results In 7 cases of non-obese T2DM who underwent DJB,one patient was weaned off hypoglycemic agents with normal FPG,2hPG and HbA1c postoperatively.Five required significantly lower dosage.Nosignificant improvement in 1 case.Complete remission rate of hyperglycemia was 1/7,effective rate was 6/7,and effective rate of HbA1c was 5/7.No significant changes in BMI were observed between the preoperative and postoperative phases.Conclusion Plasma glucose level can be markedly reduced by duodenojejunal bypass in non-obese T2DM,independent of weight loss,and the mechanism remains unclear.
