多发性骨髓瘤患者332例疗效分析
다발성골수류환자332례료효분석
A multi-centers clinical study of difierent treatment outcomes of 332 patients with multiple myeloma
  • 万方数据
    中华内科杂志 중화내과잡지
    CHINESE JOURNAL OF INTERNAL MEDICINE
    2008年 2期 98-101 ,共4页

    薛恺%邱录贵%刘霆%侯健%黄晓军%马军%陈协群%于力%金洁%吴德沛%武永吉%孟凡义%李建勇%陈文明%王椿%王建民%黄梓伦%邹萍%娄世锋%欧阳建%周凡%杜新%沈志祥

    설개%구록귀%류정%후건%황효군%마군%진협군%우력%금길%오덕패%무영길%맹범의%리건용%진문명%왕춘%왕건민%황재륜%추평%루세봉%구양건%주범%두신%침지상

    多发性骨髓瘤%治疗结果%多中心研究 多髮性骨髓瘤%治療結果%多中心研究
    다발성골수류%치료결과%다중심연구
    Multiple myeloma%Treatment outcome%Muhicenter studies
    目的 回顾性总结国内多发性骨髓瘤(MM)患者的临床特征、治疗结果 ,以提高和改善对MM患者的疗效.方法回顾分析2002年1月1日至12月31日间国内22家医院332例初诊的MM病例.对这些患者进行为期3年的随访.结果 一线治疗方案中,325例患者选择化疗,占97.9%,7例患者选择造血干细胞移植(SCT),占2.1%;共有197例(59.4%)患者接受了二线治疗,其中选择化疗和SCT的分别为190例(96.5%)和7例(3.6%);共有92例(27.7%)患者接受了三线治疗,其中选择化疗和SCT的分别为88例(95.7%)和4例(4.4%).主要药物不良事件为危及生命的感染19.3%、严重贫血19.3%、深静脉血栓1.2%、血小板减少16.9%、中性粒细胞减少性发热18.1%.结论 一些传统MM治疗方案有一定疗效并适合不同患者,期待新的治疗方法 进一步改善患者预后.
    목적 회고성총결국내다발성골수류(MM)환자적림상특정、치료결과 ,이제고화개선대MM환자적료효.방법회고분석2002년1월1일지12월31일간국내22가의원332례초진적MM병례.대저사환자진행위기3년적수방.결과 일선치료방안중,325례환자선택화료,점97.9%,7례환자선택조혈간세포이식(SCT),점2.1%;공유197례(59.4%)환자접수료이선치료,기중선택화료화SCT적분별위190례(96.5%)화7례(3.6%);공유92례(27.7%)환자접수료삼선치료,기중선택화료화SCT적분별위88례(95.7%)화4례(4.4%).주요약물불량사건위위급생명적감염19.3%、엄중빈혈19.3%、심정맥혈전1.2%、혈소판감소16.9%、중성립세포감소성발열18.1%.결론 일사전통MM치료방안유일정료효병괄합불동환자,기대신적치료방법 진일보개선환자예후.
    Objective To describe the demographic and clinical characteristics of patients with the diagnosis of multiple myeloma(MM)and to analyse the outcome of difierent regimens for the treatment of MM.Methods The study reviewed 332 MM cases diagnosed within the period from January 1,2002 to December 31,2002.These patients were tracked via their records to a total period of three years.Results First-line treatment:Totally 332 patients were included,among them 325(97.9%)patients received chemotherapy and 7(2.1%)patients received stem cell transplantation(SCT);Second-line treatment:197 patients were included,among them 190(96.5%)patients received chemotherapy and 7(3.6%)patients received SCT;Third-line treatment:92 patients were included,among them 88(95.7%)patients received chemotherapy and 4(4.4%)patients received SCT.Major adverse effects were follows:severe infection 19.3%,severe anaemia 19.3%,phlebothrombosis 1.2%,thrombocytopenia 16.9%,fever associated with neutropenia 18.1%.Conclusions Some curative effects can be achieved by using traditional treatment plans to treat patients suffering from MM,but new methods are expected to improve the prognosis.
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