CAJ | 학술논문

目的分析一组特殊的良性儿童部分性癫(癎)的临床特征,探讨其病理生理机制.方法对在我院癫(癎)中心门诊就诊的儿童部分性癫(癎)进行随访观察,纳入符合良性部分性癫(癎)诊断者,排除能够分类的其他类型,分析患者的临床和脑电图特征.结果入组的44例患者中,38.6%(17/44)的患儿每天均有发作,额叶失神、偏转是最常见的发作症状,觉醒脑电图有局灶、多灶、全面性棘慢波爆发3种表现,且以额部为著;睡眠时双侧同步化.截止随访日,88.6%(39/44)完全无发作,22.7%(10/44)脑电图完全恢复正常.结论有一组特殊的良性儿童部分性癫(癎),可能是起源于额叶.
목적 분석일조특수적량성인동부분성전(간)적림상특정,탐토기병리생리궤제.방법 대재아원전(간)중심문진취진적인동부분성전(간)진행수방관찰,납입부합량성부분성전(간)진단자,배제능구분류적기타류형,분석환자적림상화뇌전도특정.결과 입조적44례환자중,38.6%(17/44)적환인매천균유발작,액협실신、편전시최상견적발작증상,각성뇌전도유국조、다조、전면성극만파폭발3충표현,차이액부위저;수면시쌍측동보화.절지수방일,88.6%(39/44)완전무발작,22.7%(10/44)뇌전도완전회복정상.결론 유일조특수적량성인동부분성전(간),가능시기원우액협.
Objective To investigate clinical features and the pathophysiology of 43 children with atypical idiopathic partial epilepsies of childhood(IPEC)that is unclassified according to the International League Against Epilepsy classification.Methods All the children with partial epilepsy of childhood in out hospital were followed up,including those age-related cases with benign process and excluding those with benign epilepsy of childhood with centro-temporal EEG foci,Panayiotopoulos type and Gastaut type.We reviewed their EEGs,seizures and therapeutic data to analyze the semiologieal characters and the interietal activities during they were awake and sleeping.Results The average age of onset of epilepsy was 8.84years old.Frontal absences(43.2%),adversive seizures(47.7%)were more common.Everyday seizures occurred in 38.6%of patients and monthly seizures in 56.8%of patients.Atypical focal(43.2%),multifocal(27.3%),and generalized spike and waves(29.5%),were more predominant in frontal location when they were awake.During sleep,sharp waves generalized or the amplitude increased.At the last follow-up,88.6%of patients were in complete clinical remission and EEG in 22.7%of cases was normal.Among them 2 patients had stopped taking antiepileptic drugs(AEDs)and 6 patients were reducing the doses of AEDs.EEG Was abnormal only in sleep or decreased synchronization.The patients were more responsive to earbamazepine combined with sodium valproate(P<0.01).Conclusion Special partial epileptic syndrome is age-related,having excellent prognosis,which might origin from the frontal lobe.