CAJ | 학술논문

目的：研究脂蛋白(a)[Lp(a)]与绝经后女性冠心病(CHD)的关系，并初步探讨内源性雌激素对血清Lp(a)水平的影响。方法：采用ELISA法测定52例绝经后女性CHD患者及48例健康者的血清Lp(a)浓度，并测定了其中40例CHD患者和30例健康者的雌激素水平。结果：CHD组平均Lp(a)浓度显著高于对照组[(252.9±31.5)∶(129.2±20.0)mg/L，P＜0.01]，且与冠状动脉病变支数相关，r=0.398，P＜0.001；而血清Lp(a)浓度与雌二醇水平未见显著关联。结论：血清Lp(a)水平的增加是CHD的独立危险因子，也是冠状动脉病变严重程度的一个预测因素，其浓度与内源性雌激素水平无关。
목적：연구지단백(a)[Lp(a)]여절경후녀성관심병(CHD)적관계，병초보탐토내원성자격소대혈청Lp(a)수평적영향。방법：채용ELISA법측정52례절경후녀성CHD환자급48례건강자적혈청Lp(a)농도，병측정료기중40례CHD환자화30례건강자적자격소수평。결과：CHD조평균Lp(a)농도현저고우대조조[(252.9±31.5)∶(129.2±20.0)mg/L，P＜0.01]，차여관상동맥병변지수상관，r=0.398，P＜0.001；이혈청Lp(a)농도여자이순수평미견현저관련。결론：혈청Lp(a)수평적증가시CHD적독립위험인자，야시관상동맥병변엄중정도적일개예측인소，기농도여내원성자격소수평무관。
Objective:To evaluate the correlation between the Lp(a)concentration and coronary heart disease (CHD) in postmenopausal women, and to approach the effects of endogenous estrogen level on the serum Lp(a). Method:Serum Lp(a) concentrations were measured in 100 postmenopausal women with or without CHD by ELISA. Serum estradiol (E2) level was determined in 70 women. Result:Women suffered from CHD had significant higher Lp(a) concentrations than controls [(252.9±31.5)vs(129.2±20.0)mg/L, P＜0.01]. Logistic regression analysis showed that the serum Lp(a) concentration was significantly correlated with CHD, and increase in serum Lp(a) was an independent risk factor (the adjusted OR is 4.54, P＜0.01). Serum Lp(a) values had a grade association with the severity of CHD (the spearman rank correlation coefficient is 0.398, P＜0.001). Whereas the serum E2 had no correlation with Lp(a) concentration. Conclusion:Our result indicates that elevated Lp(a) is an independent risk factor for CHD in postmenopausal women, and is a predictor for the severity of CHD. The serum Lp(a) concentration does not correlated with the endogenous estrogen level.