CAJ | 학술논문

目的:探讨脆性组氨酸三联体基因(fragile histidine trail,FHIT)蛋白在38例溃疡性结肠炎(ulcerative colitis,UC)、25例Crohn's病、11例UC相关性腺癌和13例正常对照组中的表达情况. 方法:标本常规石蜡包埋,采用免疫组化法检测FHIT在UC、Crohn's病、UC相关性腺癌和正常对照组中的表达. 结果:38例UC中,25例FHIT蛋白表达阴性;25例Crohn's病中,19例表达阴性;11例UC相关性腺癌中,6例表达阴性.FHIT蛋白在UC和正常对照组(71.43% vs 7.69%,x2=18.80,P＜0.01)、Crohn's病和正常对照组(76%vs 7.69%,x2=18.88,P＜0.01)、UC相关性腺癌和正常对照组(54.55% vs 7.69%,X2=7.75,P＜0.05)间均有显著性差异;而在UC和UC相关性腺癌中无显著性差异(54.55% vs 71.43%,X2=0.05,P＞0.05). 结论:FHIT蛋白在炎症性肠病(inflammatory bowel disease,IBD)和UC相关性腺癌中呈低表达或缺失,提示该基因可能与IBD和UC相关性腺癌发生有关.
목적:탐토취성조안산삼련체기인(fragile histidine trail,FHIT)단백재38례궤양성결장염(ulcerative colitis,UC)、25례Crohn's병、11례UC상관성선암화13례정상대조조중적표체정황. 방법:표본상규석사포매,채용면역조화법검측FHIT재UC、Crohn's병、UC상관성선암화정상대조조중적표체. 결과:38례UC중,25례FHIT단백표체음성;25례Crohn's병중,19례표체음성;11례UC상관성선암중,6례표체음성.FHIT단백재UC화정상대조조(71.43% vs 7.69%,x2=18.80,P＜0.01)、Crohn's병화정상대조조(76%vs 7.69%,x2=18.88,P＜0.01)、UC상관성선암화정상대조조(54.55% vs 7.69%,X2=7.75,P＜0.05)간균유현저성차이;이재UC화UC상관성선암중무현저성차이(54.55% vs 71.43%,X2=0.05,P＞0.05). 결론:FHIT단백재염증성장병(inflammatory bowel disease,IBD)화UC상관성선암중정저표체혹결실,제시해기인가능여IBD화UC상관성선암발생유관.