CAJ | 학술논문

探讨了光激发纳米TiO_2对胃癌SGC-7901细胞的杀伤作用, 考察了在不同纳米TiO_2浓度及不同光照时间下纳米TiO_2的抑瘤效果, 并探讨了抑瘤机制. 结果表明, 光激发纳米TiO_2对胃癌SGC-7901细胞具有明显的抑制作用, 其过程类似一级反应的动力学规律;当纳米TiO_2浓度为300 μg/mL时, 对胃癌SGC-7901细胞表现出较强的杀伤效果, 其主要表现形式有两种, 即细胞坏死和细胞凋亡, 是由光激发条件下, 纳米TiO_2表面产生的活性氧组分对肿瘤细胞的有效杀伤所致.
탐토료광격발납미TiO_2대위암SGC-7901세포적살상작용, 고찰료재불동납미TiO_2농도급불동광조시간하납미TiO_2적억류효과, 병탐토료억류궤제. 결과표명, 광격발납미TiO_2대위암SGC-7901세포구유명현적억제작용, 기과정유사일급반응적동역학규률;당납미TiO_2농도위300 μg/mL시, 대위암SGC-7901세포표현출교강적살상효과, 기주요표현형식유량충, 즉세포배사화세포조망, 시유광격발조건하, 납미TiO_2표면산생적활성양조분대종류세포적유효살상소치.
Damaging effects of photoexcited TiO_2 nanoparticles on gastric cancer SGC-7901 cells were investigated. The influences of nanosized TiO_2 content, and irradiation time on cancer inhibition were systematically studied, and the inhibition mechanism was primarily discussed. The results demonstrate that photoexcited TiO_2 nanoparticles exhibit good inhibition effects on gastric cancer SGC-7901 cells, and this process follows approximately first-order reaction rule. While the concentration of TiO_2 nanoparticles is about 300 ug/mL, the damaging effects are rather remarkable. In addition, the exhibition forms of gastric cancer SGC-7901 cells are apoptosis and necrosis in killing experiments. Taken together, damaging effects of photoexcited TiO_2 nanoparticles on gastric cancer SGC-7901 cells might be attributed to the reactive oxygen species formed on the TiO_2 nanoparticles surface.