CAJ | 학술논문

霍乱毒素(CT)是霍乱弧菌分泌的一种不耐热肠毒素,具有很强的免疫原性和佐剂活性.CT本身有很强的毒副作用,如何既能具备优良的佐剂活性而又没有明显的毒副作用是当前研究的主要目标.CT及其亚单位因其独特的生理功能已被广泛地应用到很多新的免疫与疫苗策略中,已成为当前重要的佐剂之一.
곽란독소(CT)시곽란호균분비적일충불내열장독소,구유흔강적면역원성화좌제활성.CT본신유흔강적독부작용,여하기능구비우량적좌제활성이우몰유명현적독부작용시당전연구적주요목표.CT급기아단위인기독특적생리공능이피엄범지응용도흔다신적면역여역묘책략중,이성위당전중요적좌제지일.
Cholera toxin (CT) is a cholera-secreted, heat-labile enterotoxin with potent adjuvant and immunomodulatory activities. It has been well studied as a mucosal immunity adjuvant. It seems that the adjuvant efffect of CT is tightly associated with its toxicity. How to balance its adjuvant activity and toxicity becomes the major concern in the recent studies. The unique advantage of both CT and its subunits has been extensively employed in new vaccine development strategy.