CAJ | 학술논문

目的比较近距离放射治疗与根治性前列腺切除术治疗局限性前列腺癌的疗效.方法通过PubMed、万方、中国生物医学文献光盘数据库(CBMdisc)、荷兰医学文献数据库(EMBASE)、Ovid、Cochrane Library数据库收集已发表的有关局限性前列腺癌近距离放射治疗与根治性前列腺切除术疗效的随机对照研究文献,按预设的标准进行筛选,对纳入研究进行质量评价,并提取5年无生化复发生存率作为终点指标,使用Cochrane系统评价软件RevMan 5.0完成Meta分析.结果经筛选,共纳入6个研究,总样本量5903例,其中近距离放疗组3323例,根治性前列腺切除术组2580例.分析结果显示2种治疗方法的5年无生化复发生存率合并OR为1.00(95％ CI:0.69～1.45),P=0.99,差异无统计学意义.结论局限性前列腺癌近距离放射治疗与根治性前列腺切除术疗效相当,且更具优势.但纳入文献和样本量有限,今后还需增大样本,提供更好的循证证据.
목적 비교근거리방사치료여근치성전렬선절제술치료국한성전렬선암적료효.방법 통과PubMed、만방、중국생물의학문헌광반수거고(CBMdisc)、하란의학문헌수거고(EMBASE)、Ovid、Cochrane Library수거고수집이발표적유관국한성전렬선암근거리방사치료여근치성전렬선절제술료효적수궤대조연구문헌,안예설적표준진행사선,대납입연구진행질량평개,병제취5년무생화복발생존솔작위종점지표,사용Cochrane계통평개연건RevMan 5.0완성Meta분석.결과 경사선,공납입6개연구,총양본량5903례,기중근거리방료조3323례,근치성전렬선절제술조2580례.분석결과현시2충치료방법적5년무생화복발생존솔합병OR위1.00(95％ CI:0.69～1.45),P=0.99,차이무통계학의의.결론 국한성전렬선암근거리방사치료여근치성전렬선절제술료효상당,차경구우세.단납입문헌화양본량유한,금후환수증대양본,제공경호적순증증거.
Objective To compare the therapeutic effect of brachytherapy and radical prostatectomy for localized prostate cancer using a Meta-analysis.Methods The published data with randomized control trials (RCT) on comparison of brachytherapy and radical prostatectomy for the treatment of localized prostate cancer in PubMed,Wanfang database,Chinese Biomedical Literature Database ( CBMdisc),the Excerpta Medica Database (EMBASE),Ovid and Cochrane library were searched and screened.The quality of the studies included was evaluated and the data with 5-year event free survival rate for comparison were extracted.Meta-analysis was performed by RevMan 5.0 (Cochrane reviews software).Results From six trials,there were 5903 patients that were eligible for the analysis,in which 3323 patients were treated by brachytherapy and other 2580 by radical prostatectomy.The odds ratio of all trials was 1.00 (95％ CI:0.69-1.45,P =0.99 ) and there was no significant difference of 5-year event free survival rate between two treatment groups.Conclusion This Meta analysis shows that brachytherapy may have comparable treatment effect than radical prostatectomy.