中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
11期
1450-1452
,共3页
荆靓艳%王慧玲%薛欣%谢广宏
荊靚豔%王慧玲%薛訢%謝廣宏
형정염%왕혜령%설흔%사엄굉
防耐药变异浓度%氟喹诺酮类药物%凝固酶阴性葡萄球菌
防耐藥變異濃度%氟喹諾酮類藥物%凝固酶陰性葡萄毬菌
방내약변이농도%불규낙동류약물%응고매음성포도구균
Mutant prevention concentration%Fluoroquinolones%Coagulase negative staphylococcus
目的 比较6种氟喹诺酮类药物对临床分离凝固酶阴性葡萄球菌耐药突变体的选择能力.方法 选择呼吸道标本,对苯唑西林、环丙沙星敏感的凝固酶阴性葡萄球菌34株,采用标准琼脂二倍稀释法、标准琼脂平板稀释法,测定6种氟喹诺酮类药物对凝固酶阴性葡萄球菌的最低抑菌浓度(MIC)、防耐药变异浓度(MPC).结果 MPC值比较,莫西沙星最低(MPC90为1 mg/L),左氧氟沙星和环丙沙星最高(MPC90均为32 mg/L).莫西沙星、卡屈沙星和加替沙星的MPC90/MIC90较低,均为2.结论 莫西沙星、卡屈沙星和加替沙星对凝固酶阴性葡萄球菌的MPC值较低,突变选择窗范围相对较窄.
目的 比較6種氟喹諾酮類藥物對臨床分離凝固酶陰性葡萄毬菌耐藥突變體的選擇能力.方法 選擇呼吸道標本,對苯唑西林、環丙沙星敏感的凝固酶陰性葡萄毬菌34株,採用標準瓊脂二倍稀釋法、標準瓊脂平闆稀釋法,測定6種氟喹諾酮類藥物對凝固酶陰性葡萄毬菌的最低抑菌濃度(MIC)、防耐藥變異濃度(MPC).結果 MPC值比較,莫西沙星最低(MPC90為1 mg/L),左氧氟沙星和環丙沙星最高(MPC90均為32 mg/L).莫西沙星、卡屈沙星和加替沙星的MPC90/MIC90較低,均為2.結論 莫西沙星、卡屈沙星和加替沙星對凝固酶陰性葡萄毬菌的MPC值較低,突變選擇窗範圍相對較窄.
목적 비교6충불규낙동류약물대림상분리응고매음성포도구균내약돌변체적선택능력.방법 선택호흡도표본,대분서서림、배병사성민감적응고매음성포도구균34주,채용표준경지이배희석법、표준경지평판희석법,측정6충불규낙동류약물대응고매음성포도구균적최저억균농도(MIC)、방내약변이농도(MPC).결과 MPC치비교,막서사성최저(MPC90위1 mg/L),좌양불사성화배병사성최고(MPC90균위32 mg/L).막서사성、잡굴사성화가체사성적MPC90/MIC90교저,균위2.결론 막서사성、잡굴사성화가체사성대응고매음성포도구균적MPC치교저,돌변선택창범위상대교착.
Objective To determine the mutant prevention concentration (MPC) of 6 kinds of fluoroquinolones for the clinical isolated coagulase negative staphylococcus,and to compare the 6 kinds of fluoroquinolones.Methods The minimal inhibitory concentrations (MIC) and the mutant prevention concentration (MPC) of ciprofloxacin,levofloxacin,gatifloxacin,cadrofloxacin,moxifloxacin and pazufloxacin were determined with 34 strains of coagulase negative staphylococcus isolated which were sensitive to oxacillin and ciprofloxacin by agar two-fold dilution method and ager plates dilution method.Results For MPC9o,moxifloxacin was the lowest (1 mg/L).Cadrofloxacin,gatifloxacin and pazufloxacin,levofloxacin and ciprofloxacin were the highest among the 6 kinds of fluoroquinolones against coagulase negative staphylococcus which were 32 mg/L; as for MIC90/MPC90,moxifloxacin,cadrofloxacin and gatifloxacin were lower; pazufloxacin,levofloxacin and ciprofloxacin were higher.The comparison of the pharmacokinetics parameter in vivo for the 6 kinds of fluoroquinolones against the 34 strains of coagulase negative staphylococcus showed that MPC90 was less than Cmax for moxifloxacin and cadrofloxacin,and was similar to gatifloxacin.Conclusion Moxifloxacin,cadrofloxacin and gatifloxacin have a lower MPC and narrower mutant selective window with a high ability to restrict the selection of coagulase negative staphylococcus resistant mutants among the 6 kinds of fluoroquinolones against the coagulase negative staphylococcus.
