中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2009年
3期
299-300
,共2页
李秋桂%蒋建华%张宝%马秦%肖永康
李鞦桂%蔣建華%張寶%馬秦%肖永康
리추계%장건화%장보%마진%초영강
脂肪细胞型脂肪酸结合蛋白%肥胖症%代谢综合征
脂肪細胞型脂肪痠結閤蛋白%肥胖癥%代謝綜閤徵
지방세포형지방산결합단백%비반증%대사종합정
Adipocyte fatty acid-binding protein%Obesity%Metabolic syndrome
代谢综合征(MS)组(n=121)的血清脂肪细胞型脂肪酸结合蛋白(A-FABP)水平较对照组(n=120)显著升高[(14.7±4.8 vs 6.8±3.0)μg/L,P<0.001].腹型肥胖MS患者的血清A-FABP水平较非腹型肥胖MS患者显著升高[(15.7±4.2 vs 12.6±5.1)μg/L,P<0.001].血清A-FABP水平与体重指数、腰围、腰臀比、空腹胰岛素、稳态模型评估的胰岛素抵抗指数、空腹血糖、甘油三酯、总胆同醇及平均动脉压等指标均呈正相关(r分别为0.603、0.534、0.411、0.424、0.401、0.370、0.460、0.208和0.522,均P<0.05),而与HDL-C旱显著负相关(r=-0.448,P<0.001).
代謝綜閤徵(MS)組(n=121)的血清脂肪細胞型脂肪痠結閤蛋白(A-FABP)水平較對照組(n=120)顯著升高[(14.7±4.8 vs 6.8±3.0)μg/L,P<0.001].腹型肥胖MS患者的血清A-FABP水平較非腹型肥胖MS患者顯著升高[(15.7±4.2 vs 12.6±5.1)μg/L,P<0.001].血清A-FABP水平與體重指數、腰圍、腰臀比、空腹胰島素、穩態模型評估的胰島素牴抗指數、空腹血糖、甘油三酯、總膽同醇及平均動脈壓等指標均呈正相關(r分彆為0.603、0.534、0.411、0.424、0.401、0.370、0.460、0.208和0.522,均P<0.05),而與HDL-C旱顯著負相關(r=-0.448,P<0.001).
대사종합정(MS)조(n=121)적혈청지방세포형지방산결합단백(A-FABP)수평교대조조(n=120)현저승고[(14.7±4.8 vs 6.8±3.0)μg/L,P<0.001].복형비반MS환자적혈청A-FABP수평교비복형비반MS환자현저승고[(15.7±4.2 vs 12.6±5.1)μg/L,P<0.001].혈청A-FABP수평여체중지수、요위、요둔비、공복이도소、은태모형평고적이도소저항지수、공복혈당、감유삼지、총담동순급평균동맥압등지표균정정상관(r분별위0.603、0.534、0.411、0.424、0.401、0.370、0.460、0.208화0.522,균P<0.05),이여HDL-C한현저부상관(r=-0.448,P<0.001).
Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects [n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity [(15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001).
