CAJ | 학술논문

目的探讨惊恐障碍患者对情感刺激相关的杏仁核时程反应.方法 13例首次发病、未经治疗的惊恐障碍患者(惊恐障碍组)和13名健康个体(对照组)在被动注视任务下行功能磁共振成像(fMRI)；采用感兴趣区分析方法,比较2组被试的杏仁核在正性、中性和负性情绪图片任务下组块间的血氧依赖信号时间反应特征,并对情绪图片愉悦度等评分.结果 (1)对正性任务,左侧杏仁核存在“组×时间”交互作用[F(4,96) =4.89,P＜0.01],右侧杏仁核表现时间效应[F(4,96)=4.85,P＜0.01],2组均呈激活强度显著降低形式；(2)对负性图片被动注视任务,右侧杏仁核表现显著的组间差异[F(1,24) =9.01,P＜0.01],惊恐障碍组强于对照组；(3)中性图片被动注视任务条件下,惊恐障碍组和对照组双侧杏仁核在组水平、时间水平和组×时间交互作用的差异无统计学意义(均P＞ 0.05).结论惊恐障碍患者表现为杏仁核对正性和负性情绪图片反应敏感、增强,从fMRI方面支持惊恐障碍患者情绪反应敏感的假设.
목적 탐토량공장애환자대정감자격상관적행인핵시정반응.방법 13례수차발병、미경치료적량공장애환자(량공장애조)화13명건강개체(대조조)재피동주시임무하행공능자공진성상(fMRI)；채용감흥취구분석방법,비교2조피시적행인핵재정성、중성화부성정서도편임무하조괴간적혈양의뢰신호시간반응특정,병대정서도편유열도등평분.결과 (1)대정성임무,좌측행인핵존재“조×시간”교호작용[F(4,96) =4.89,P＜0.01],우측행인핵표현시간효응[F(4,96)=4.85,P＜0.01],2조균정격활강도현저강저형식；(2)대부성도편피동주시임무,우측행인핵표현현저적조간차이[F(1,24) =9.01,P＜0.01],량공장애조강우대조조；(3)중성도편피동주시임무조건하,량공장애조화대조조쌍측행인핵재조수평、시간수평화조×시간교호작용적차이무통계학의의(균P＞ 0.05).결론 량공장애환자표현위행인핵대정성화부성정서도편반응민감、증강,종fMRI방면지지량공장애환자정서반응민감적가설.
Objective To explore the behavioral and related amygdalar temporal response to emotional pictures in individuals with panic disorder (PD).Methods Functional magnetic resonance imaging (fMRI) was adopted to examine the neural substrates of emotional pictures processing in 13 firstepisode unmedicated PD subjects (PD) and 13 healthy controls.Analyses focused on the temporal dynamics of the blood-oxygen level dependant (BOLD) signal change in the amygdala across blocks of positive,neutral and negative emotional pictures in PD versus healthy controls.The valence score was also recorded to emotional pictures.Results ( 1 ) For positive pictures task,left amygdale showed " Group × Time"interaction effect [ F (4,96 ) =4.89,P ＜ 0.01 ] ; right amygdale presented temporal effect [ F ( 4,96 ) =4.85,P ＜ 0.01 ].(2) For negative pictures task,right amygdala showed significant temporal difference [ F( 1,24) =9.01,P ＜ 0.01 ],which PD group was stronger than control group.(3)For negative pictures task,the bilateral amygdala did not present statistical difference ( all P ＞ 0.05 ).Conclusions The augmented and sensitive amygdalar responses to positive and negative IAPS pictures in patients with PD compared with the healthy controls participants support the hypothesis of sensitive and augmented response in panic disorder.