CAJ | 학술논문

甲状腺素是调节人体细胞分化、生长及代谢的重要激素.研究显示,甲状腺素可以与细胞表面的整合素ανβ3受体结合,参与肿瘤血管生成的过程.而其结构类似物四碘甲腺乙酸则可以通过抑制甲状腺素与整合素ανβ3结合而产生抑制肿瘤血管生成的过程.对甲状腺素促肿瘤血管生成作用的研究,将为肿瘤分子靶向治疗提供了新的思路.
갑상선소시조절인체세포분화、생장급대사적중요격소.연구현시,갑상선소가이여세포표면적정합소ανβ3수체결합,삼여종류혈관생성적과정.이기결구유사물사전갑선을산칙가이통과억제갑상선소여정합소ανβ3결합이산생억제종류혈관생성적과정.대갑상선소촉종류혈관생성작용적연구,장위종류분자파향치료제공료신적사로.
Thyroid hormone is an important hormone for regulating cell differentiation,growth and metabolism.Many studies have shown that thyroid hormone can induce turmor angiogenesis after binding with the integrin ανβ3 receptor at cell surface.Tetraiodothyroacetic acid is the analogue of thyroid hormone,and can inhibit tumor angiogenesis by inhibiting the binding of thyroid hormone with integrin ανβ3.Studying the role of thyroid hormone in promoting tumor angiogenesis may provide a new approach for molecular targeted therapy of tumor.