CAJ | 학술논문

目的观察莫沙必利和多潘立酮对卧床、鼻饲的急性脑卒中患者医院内肺部感染发生率的影响.方法 89例卧床、鼻饲的急性脑卒中患者,采用随机数字表法分为研究组(47例)和对照组(42例),两组均给予脑卒中常规治疗,研究组在此基础上服用莫沙必利5 mg,多潘立酮20 mg,每日3次,连续4周.观察住院4周内两组患者肺部感染发生率及鼻饲后3 h胃内容物残留例次及残留量,并进行统计学分析.结果住院4周内,研究组肺部感染13例,对照组25例,发生率分别为27.66%(13/47)和59.52%(25/42),两组比较差异有统计学意义(P<0.01).鼻饲后3 h鼻胃管中可抽出食物的患者共26l例次,其中对照组237例次,残留量(112.17±32.54)ml;研究组24例次,残留量(50.80±15.38)ml,两组患者鼻饲后3 h有胃内容物残留的例次及残留量比较差异均有统计学意义(P<0.01).结论对于卧床、鼻饲的急性脑卒中患者,在常规治疗基础上服用莫沙必利和多潘立酮,可显著降低患者医院内肺部感染发生率.
목적 관찰막사필리화다반립동대와상、비사적급성뇌졸중환자의원내폐부감염발생솔적영향.방법 89례와상、비사적급성뇌졸중환자,채용수궤수자표법분위연구조(47례)화대조조(42례),량조균급여뇌졸중상규치료,연구조재차기출상복용막사필리5 mg,다반립동20 mg,매일3차,련속4주.관찰주원4주내량조환자폐부감염발생솔급비사후3 h위내용물잔류례차급잔류량,병진행통계학분석.결과 주원4주내,연구조폐부감염13례,대조조25례,발생솔분별위27.66%(13/47)화59.52%(25/42),량조비교차이유통계학의의(P<0.01).비사후3 h비위관중가추출식물적환자공26l례차,기중대조조237례차,잔류량(112.17±32.54)ml;연구조24례차,잔류량(50.80±15.38)ml,량조환자비사후3 h유위내용물잔류적례차급잔류량비교차이균유통계학의의(P<0.01).결론 대우와상、비사적급성뇌졸중환자,재상규치료기출상복용막사필리화다반립동,가현저강저환자의원내폐부감염발생솔.
Objective To study the effects of mosapride and domperidone on the pulmonary infection of acute stroke patients lying in bed and with nasal feeding. Methods Eighty-nine acute stroke patients lying in bed and with nasal feeding were divided randomly into the treatment group (47 cases) and the control group (42 cases). The control group was treated routinely,and the treatment group was treated with mosapride 5 mg and domporidone 20 mg thrice a day for 4 weeks, besides routine therapy. The incidence rate of pulmonary infection, gastric residual volume (GRV) and the number of cases with gastric contents remaining after 3 hours of nasal feeding were studied. All data were analyzed statistically. Results In the treatment group, 13 cases had pulmonary infection,and the incidence rate was 27.66%(13/47). In the control group,25 cases had pulmonary infection,and the incidence rate was 59.52% (25/42). There was significant difference between the two groups (P < 0.01 ). Three hours after nasal feeding,24 cases with gastric contents remaining were discovered in the treatment group,and GRV was (50.80±15.38) ml. Two hundred and thirty-seven cases with gastric contents remaining were discovered in the control group, and GRV was (112.17±32.54) ml. Significance differences were also detected between the two groups (P<0.01). Conclusion As for the acute stroke patients lying in bed and with nasal feeding,mosapride and domperidone can remarkably cut down the pulmonary infection upon common treatment.