中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
6期
627-629
,共3页
张利容%毛细云%潘辉%欧霞
張利容%毛細雲%潘輝%歐霞
장리용%모세운%반휘%구하
痴呆%事件相关电位%P300%脑电图
癡呆%事件相關電位%P300%腦電圖
치태%사건상관전위%P300%뇌전도
Dementia%Event-related potentials%P300%Electroencephalogram
目的 探讨事件相关电位和脑电图对早期痴呆的诊断价值.方法 选择2008年6月至2011年7月我院门诊及住院的痴呆患者113例,选择同期健康体检者100名为健康对照组,分别进行P300检测和脑电图检测,比较其差异.结果 (1)与健康对照组相比,痴呆组P300潜伏期延长[(402.5 ±37.4)、(320.4±23.5)ms],差异有统计学意义(t=19.40,P=0.02),P300波幅降低[(3.76±1.76)、(5.32±1.38) μV],差异有统计学意义(t=7.24,P=0.01).(2)痴呆组脑电图异常68例(60.2％),健康对照组34例(34.0％),脑电图异常率差异有统计学意义(x2 =13.54,P＜0.01),两组脑电图中度异常[26.5％ (18/68)与5.9％ (2/34)]和重度异常[8.8％ (6/68)与2.9％ (1/34)]比例差异有统计学意义(x2值分别为4.85、1.22,P值均为0.02),轻度异常和界限性比例差异无统计学意义(P均＞0.05).结论 P300是诊断早期痴呆特异性较强的客观指标,脑电图可为痴呆患者脑功能损伤提供依据.
目的 探討事件相關電位和腦電圖對早期癡呆的診斷價值.方法 選擇2008年6月至2011年7月我院門診及住院的癡呆患者113例,選擇同期健康體檢者100名為健康對照組,分彆進行P300檢測和腦電圖檢測,比較其差異.結果 (1)與健康對照組相比,癡呆組P300潛伏期延長[(402.5 ±37.4)、(320.4±23.5)ms],差異有統計學意義(t=19.40,P=0.02),P300波幅降低[(3.76±1.76)、(5.32±1.38) μV],差異有統計學意義(t=7.24,P=0.01).(2)癡呆組腦電圖異常68例(60.2％),健康對照組34例(34.0％),腦電圖異常率差異有統計學意義(x2 =13.54,P＜0.01),兩組腦電圖中度異常[26.5％ (18/68)與5.9％ (2/34)]和重度異常[8.8％ (6/68)與2.9％ (1/34)]比例差異有統計學意義(x2值分彆為4.85、1.22,P值均為0.02),輕度異常和界限性比例差異無統計學意義(P均＞0.05).結論 P300是診斷早期癡呆特異性較彊的客觀指標,腦電圖可為癡呆患者腦功能損傷提供依據.
목적 탐토사건상관전위화뇌전도대조기치태적진단개치.방법 선택2008년6월지2011년7월아원문진급주원적치태환자113례,선택동기건강체검자100명위건강대조조,분별진행P300검측화뇌전도검측,비교기차이.결과 (1)여건강대조조상비,치태조P300잠복기연장[(402.5 ±37.4)、(320.4±23.5)ms],차이유통계학의의(t=19.40,P=0.02),P300파폭강저[(3.76±1.76)、(5.32±1.38) μV],차이유통계학의의(t=7.24,P=0.01).(2)치태조뇌전도이상68례(60.2％),건강대조조34례(34.0％),뇌전도이상솔차이유통계학의의(x2 =13.54,P＜0.01),량조뇌전도중도이상[26.5％ (18/68)여5.9％ (2/34)]화중도이상[8.8％ (6/68)여2.9％ (1/34)]비례차이유통계학의의(x2치분별위4.85、1.22,P치균위0.02),경도이상화계한성비례차이무통계학의의(P균＞0.05).결론 P300시진단조기치태특이성교강적객관지표,뇌전도가위치태환자뇌공능손상제공의거.
Objective To identify the potential value of event-related potentials ( ERPs ) and electroencephalogram(EEG) in early diagnosis of dementia.Methods From June 2008 to July 2011,113 patients with dementia were recruited fom First Affiliated Hospital of Anhui College of Traditional Chinese Medicine.Meanwhile,100 healthy individuals conducting physical examination at this hospital were collected as the control group.P300 and EEG were measured in patients and healthy controls.Results ( 1 ) Compared with healthy controls,patients with early diagnosis of dementia had significantly longer latency(402.5 ± 37.4)ms vs.( 320.4 ± 23.5 ) ms ;t =19.40 ; P =0.02 ) and lower amplitude of P300 ( 3.76 ± 1.76 ) μV vs.( 5.32 ± 1.38 )μV;t=7.24;P=0.01 ).(2)Significant higher proportionof abnormal EEG cases was found in individuals with dementia (68/113,60.2％ ) than that of participants in the healthy control group(34/100,34.0％ ) ( x2 =13.54,P ＜0.01 ).Specifically,patients with early diagnosis of dementia had significantly higher prevalence of moderate (26.5 ％ [ 18/68 ] vs.5.9 ％ [ 2/34 ] ; x2 =4.85,P =0.02 ) and severe ( 8.8 ％ [ 6/68 ] vs.2.9 ％ [ 1/34 ] ; x2 =1.22,P =0.02 ) abnormal EEG than healthy controls,while there were no significant difference of the proportions of mild or borderline abnormal EEG between the two groups ( P ＞ 0.05 ).Conclusion P300 is an extraordinary objective indicator for early diagnosis of dementia.EEG can provide evidence of impaired brain function for individuals with dementia.
