CAJ | 학술논문

目的评价血清胃蛋白酶原(PG)对萎缩性胃炎和胃癌的筛查价值,并探索适合威海市萎缩性胃炎筛查的血清PG的最佳界值.方法 374例胃十二指肠疾病患者纳入研究,根据胃镜下活检组织病理学检查结果分为慢性浅表性胃炎、慢性萎缩性胃炎(CAG)、胃癌及消化性溃疡等四组.用免疫比浊法全自动检测血清PG水平.结果 CAG组及胃癌组血清PGI和PGR显著下降(P<0.01),胃癌组及胃体萎缩组血清PGI和PGR显著低于胃窦萎缩组(P<0.01).血清PGI和PGR筛查CAG的最佳界值分别为76.50ng/ml和3.68.结论用免疫比浊法全自动检测血清PGL及PGR水平可作为血清学筛查胃癌及萎缩性胃炎患者的有效方法,PGI<76.50 ns/ml、PGR<3.68是威海市居民筛查GAG的最佳界值.
목적 평개혈청위단백매원(PG)대위축성위염화위암적사사개치,병탐색괄합위해시위축성위염사사적혈청PG적최가계치.방법 374례위십이지장질병환자납입연구,근거위경하활검조직병이학검사결과분위만성천표성위염、만성위축성위염(CAG)、위암급소화성궤양등사조.용면역비탁법전자동검측혈청PG수평.결과 CAG조급위암조혈청PGI화PGR현저하강(P<0.01),위암조급위체위축조혈청PGI화PGR현저저우위두위축조(P<0.01).혈청PGI화PGR사사CAG적최가계치분별위76.50ng/ml화3.68.결론 용면역비탁법전자동검측혈청PGL급PGR수평가작위혈청학사사위암급위축성위염환자적유효방법,PGI<76.50 ns/ml、PGR<3.68시위해시거민사사GAG적최가계치.
Objective To evaluate the value of serum pepsinogen (PG) on atrophic gastritis and gastric cancer screening and to explore the best cut-off values of serum pepsinogen for atrophic gastritis screening in Weihai City. Methods Three hundred and sev-enty-four patients with gastroduodenal diseases were recruited, and these patients were divided into 4 groups based on endoscopic and histopathological findings:chronic superficial gastritis (CSG) group, chronic atrophic gastritis (CAG) group, gastric cancer (GC) group, and peptic ulcer (PU) group. The serum pepsinogen was detected by immunoturbidimetry. Results The PGI level and the PG Ⅰ/PGⅡ ratio (PGR) were significantly decreased in GC and CAG groups (P<0.01). The PGI level and PGR in GC and atrophic cor-pus gastritis groups were significantly different from the ones in atrophic antral gastritis group (P<0.01). The best cut-off values of the serum PGI and PGR for the atrophic gastritis screening were 76.50 ng/ml and 3.68, respectively. Conclusion The serum PGI and PGR automatic detection by immunoturbidimetry could be useful for screening gastric cancer and atrophic gastritis patients, and serum PGⅠ< 76. 50 ng/ml and PGR < 3.68 were the best cut-off values for atrophic gastritis screening in Weihai City.