CAJ | 학술논문

目的观察奥沙利铂联合替吉奥治疗结直肠癌术后化疗患者的疗效和不良反应.方法 54例结直肠癌术后患者采用奥沙利铂联合替吉奥方案治疗(奥沙利铂130 mg/m2、第1天、静脉滴注2 h;替吉奥口服40～60 ms/次、第1～14天),每3周重复1次,治疗3个周期后评价疗效.结果 54例患者中,有2例因经济原因于1个疗程后改变化疗方案,另52患者例均完成6个周期化疗.其中完全缓解6例(11.5%),部分缓解28例(53.8%),近期有效率为65.4%.直肠癌组的有效率(70.0%)略高于结肠癌组(62.5%),但差异无统计学意义(P>0.05).主要不良反应为血液学毒性、胃肠道反应和感觉神经毒性,经对症处理后患者均可耐受,无肝肾功能等严重不良反应发生,无化疗相关性死亡.结论奥沙利铂联合替吉奥作为结直肠癌术后化疗方案疗效显著,安全性高,无肝肾等严重不良反应发生,可作为结直肠癌患者术后化疗的一种供选择方案.
목적 관찰오사리박연합체길오치료결직장암술후화료환자적료효화불량반응.방법 54례결직장암술후환자채용오사리박연합체길오방안치료(오사리박130 mg/m2、제1천、정맥적주2 h;체길오구복40～60 ms/차、제1～14천),매3주중복1차,치료3개주기후평개료효.결과 54례환자중,유2례인경제원인우1개료정후개변화료방안,령52환자례균완성6개주기화료.기중완전완해6례(11.5%),부분완해28례(53.8%),근기유효솔위65.4%.직장암조적유효솔(70.0%)략고우결장암조(62.5%),단차이무통계학의의(P>0.05).주요불량반응위혈액학독성、위장도반응화감각신경독성,경대증처리후환자균가내수,무간신공능등엄중불량반응발생,무화료상관성사망.결론 오사리박연합체길오작위결직장암술후화료방안료효현저,안전성고,무간신등엄중불량반응발생,가작위결직장암환자술후화료적일충공선택방안.
Objective To observe the efficacy and side effects of the combination therapy of oxaliplatin and S-l in treating postoperative colorectal cancer patients. Methods 54 postoperative colorectal cancer patients recieved the combination therapy of oxaliplatin and S-l regimen, repeated every 3 weeks, and evaluate the efficacy after 3 cycles. Results All of the 54 patients but 2 ( changed the chemotherapy regimen after the first cycle because of economic reason) finished 6 cycles of the chemotherapy treatment. There were 6 cases (11.5%) with complete response (CR), 28 cases (53.8%) with partial response (PR), and the overall response rate was 65.4%. Major adverse effects were hematological toxicities, gastrointestinal disturbance, neurosensory toxicity. There were no chemotherapy-related deaths. Conclusions Oxaliplatin combined with S-l is an effective and better tolerated chemotherapy treatment for postoperative colorectal cancer patients, with no serious side effects for liver and kidney. Therefore, it can be used as an alternative chemotherapy regimen for postoperative colorectal cancer patients.