中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2009年
4期
346-349
,共4页
代谢性核受体%配体%转录活性调节
代謝性覈受體%配體%轉錄活性調節
대사성핵수체%배체%전록활성조절
metabolic nuclear receptor%ligand%transcriptional regulatio
代谢性核受体隶属于配体依赖性转录因子超家族,其下游效应靶基因均为主司异源性药物/毒物及内源性激素代谢功能的酶及转运蛋白,可对临床药物治疗效果及疾病易感性产生重要的影响.近年来有关代谢性核受体的功能及其转录活性调控的机制等已开始受到了关注,并已成为药物代谢动力学及临床肝病治疗学领域新的研究热点.
代謝性覈受體隸屬于配體依賴性轉錄因子超傢族,其下遊效應靶基因均為主司異源性藥物/毒物及內源性激素代謝功能的酶及轉運蛋白,可對臨床藥物治療效果及疾病易感性產生重要的影響.近年來有關代謝性覈受體的功能及其轉錄活性調控的機製等已開始受到瞭關註,併已成為藥物代謝動力學及臨床肝病治療學領域新的研究熱點.
대사성핵수체대속우배체의뢰성전록인자초가족,기하유효응파기인균위주사이원성약물/독물급내원성격소대사공능적매급전운단백,가대림상약물치료효과급질병역감성산생중요적영향.근년래유관대사성핵수체적공능급기전록활성조공적궤제등이개시수도료관주,병이성위약물대사동역학급림상간병치료학영역신적연구열점.
Metabolic nuclear receptors belong to a superfamily of ligand-activated transcription factors,which regulates the expression of enzyme and transport protein responsing for metabolizing xenobiotics and endoge-nous hormones,contributed to the therapeutic effect of drug and susceo-tility for diseases.Recenfly,it has been interested in the function of the metabolic nuclear receptors and their transcriptional regulation mecha-nism by the ligands,and the researches have been focused on pharmaco-kinectics and clinical hepatopathy treatment field.
