癌变·畸变·突变
癌變·畸變·突變
암변·기변·돌변
CARCINOGENSES,TERATOGENSIS AND MUTAGENESIS
2009年
6期
447-451
,共5页
铜%铜缺乏%脂质过氧化%超氧化物歧化酶%谷胱甘肽过氧化物酶%过氧化氢酶%丙二醛
銅%銅缺乏%脂質過氧化%超氧化物歧化酶%穀胱甘肽過氧化物酶%過氧化氫酶%丙二醛
동%동결핍%지질과양화%초양화물기화매%곡광감태과양화물매%과양화경매%병이철
copper%copper deficiency%lipid peroxidation%superoxide dismutase%glutathione peroxidase%catalase%malondialdehyde
背景与目的:探讨铜缺乏状态下,大鼠血中铜浓度及铜锌比值(Cu/Zn)与脂质过氧化各相关指标之间的关系,研究微量元素铜对大鼠脂质过氧化的影响. 材料与方法:在铜缺乏状态下测定大鼠血中铜含量及血中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-pX)、过氧化氢酶(CAT)活性水平及丙二醛(MDA)含量. 结果:42只SD大鼠随机分为正常对照组和6个实验组.对照组大鼠饲以正常饲料,实验组大鼠饲以缺铜饲料,同时灌胃给予不同剂量葡萄糖酸铜(Cu-G),各剂量实验组大鼠血中铜浓度呈现无规律波动,而Cu/Zn比值随着铜摄入量的增加呈递增趋势,差异有统计学意义(P<0.01).在铜缺乏状态下,大鼠血中SOD活力水平低于正常水平,随着铜摄入量的增加,血中铜锌比值升高,SOD活力水平呈现上升趋势.铜缺乏时血中MDA含量升高,而随着铜摄入量的增加,即铜锌比值的升高,MDA含量有所下降,并保持在较低水平.血中铜锌比值的下降可能导致大鼠血中CAT活性水平的升高,但铜锌比值与CAT活性的相关关系呈非线性相关.铜缺乏及铜摄人量对大鼠血中GSH-pX无明显影响.结论:在研究微量元素铜的生理生化作用时.对铜锌比值(Cu/Zn)进行研究更具有实际意义.在铜缺乏状态下,大鼠血中SOD活性水平下降,同时血中MDA含量上升,而随着血中铜锌比值的升高,SOD活性呈上升趋势,MDA含量下降到较低水平.而铜摄入不足会使血中CAT的活性水平升高.对GSH-pX活性水平无明显影响.
揹景與目的:探討銅缺乏狀態下,大鼠血中銅濃度及銅鋅比值(Cu/Zn)與脂質過氧化各相關指標之間的關繫,研究微量元素銅對大鼠脂質過氧化的影響. 材料與方法:在銅缺乏狀態下測定大鼠血中銅含量及血中超氧化物歧化酶(SOD)、穀胱甘肽過氧化物酶(GSH-pX)、過氧化氫酶(CAT)活性水平及丙二醛(MDA)含量. 結果:42隻SD大鼠隨機分為正常對照組和6箇實驗組.對照組大鼠飼以正常飼料,實驗組大鼠飼以缺銅飼料,同時灌胃給予不同劑量葡萄糖痠銅(Cu-G),各劑量實驗組大鼠血中銅濃度呈現無規律波動,而Cu/Zn比值隨著銅攝入量的增加呈遞增趨勢,差異有統計學意義(P<0.01).在銅缺乏狀態下,大鼠血中SOD活力水平低于正常水平,隨著銅攝入量的增加,血中銅鋅比值升高,SOD活力水平呈現上升趨勢.銅缺乏時血中MDA含量升高,而隨著銅攝入量的增加,即銅鋅比值的升高,MDA含量有所下降,併保持在較低水平.血中銅鋅比值的下降可能導緻大鼠血中CAT活性水平的升高,但銅鋅比值與CAT活性的相關關繫呈非線性相關.銅缺乏及銅攝人量對大鼠血中GSH-pX無明顯影響.結論:在研究微量元素銅的生理生化作用時.對銅鋅比值(Cu/Zn)進行研究更具有實際意義.在銅缺乏狀態下,大鼠血中SOD活性水平下降,同時血中MDA含量上升,而隨著血中銅鋅比值的升高,SOD活性呈上升趨勢,MDA含量下降到較低水平.而銅攝入不足會使血中CAT的活性水平升高.對GSH-pX活性水平無明顯影響.
배경여목적:탐토동결핍상태하,대서혈중동농도급동자비치(Cu/Zn)여지질과양화각상관지표지간적관계,연구미량원소동대대서지질과양화적영향. 재료여방법:재동결핍상태하측정대서혈중동함량급혈중초양화물기화매(SOD)、곡광감태과양화물매(GSH-pX)、과양화경매(CAT)활성수평급병이철(MDA)함량. 결과:42지SD대서수궤분위정상대조조화6개실험조.대조조대서사이정상사료,실험조대서사이결동사료,동시관위급여불동제량포도당산동(Cu-G),각제량실험조대서혈중동농도정현무규률파동,이Cu/Zn비치수착동섭입량적증가정체증추세,차이유통계학의의(P<0.01).재동결핍상태하,대서혈중SOD활력수평저우정상수평,수착동섭입량적증가,혈중동자비치승고,SOD활력수평정현상승추세.동결핍시혈중MDA함량승고,이수착동섭입량적증가,즉동자비치적승고,MDA함량유소하강,병보지재교저수평.혈중동자비치적하강가능도치대서혈중CAT활성수평적승고,단동자비치여CAT활성적상관관계정비선성상관.동결핍급동섭인량대대서혈중GSH-pX무명현영향.결론:재연구미량원소동적생리생화작용시.대동자비치(Cu/Zn)진행연구경구유실제의의.재동결핍상태하,대서혈중SOD활성수평하강,동시혈중MDA함량상승,이수착혈중동자비치적승고,SOD활성정상승추세,MDA함량하강도교저수평.이동섭입불족회사혈중CAT적활성수평승고.대GSH-pX활성수평무명현영향.
BACKGROUND AND AIM: To study the effect of trace element copper on lipid peroxidation by analyze relations among copper concentration, copper-zinc ratio (Cu/ Zn) and the biomarkers of lipid peroxidation in copper deficiency in rats. MATERIALS AND METHODS: Determined the content of copper in blood, the activities of Superoxide Dismutase (SOD), Glutathione Peroxidase (GSH-pX) and Catalase (CAT) and the content of Malondialdehyde (MDA) in copper deficiency. RESULTS: Copper-defficient rats treated with copper gluconate (Cu-G) in different doses showed fluctuating copper concentrations in the blood, while copper-zinc ratio (Cu/Zn) showed an ascending trend following the increase of copper intake and statistical significant results (P<0.01). In copper deficiency state, the SOD activity was lower than the normal level, and then followed an upward trend with increased copper intake, equivalent to the copper-zinc (Cu/ Zn) ratio. The content of MDA was higher than the normal level, and its content decreased with increasing copper intake and the Cu/Zn ratio, and remained at a relatively low level. The decreased Cu/Zn ratio could induce the increase of the CAT activity, but with no linear correlation between them. No significant effect on the GSH-pX activity in rat blood was found during inadequate copper intake. CONCLUSION: Cu-Zn ratio has more practical significance in the research of physiological and biochemical roles of the trace element copper. In copper deficiency, the SOD activity in the rat blood was lower than the normal level and the content of MDA higher. With the increase of Cu/ Zn ratio, the SOD activity increased gradually, while the content of MDA was reduced. Insufficient copper intake could enhance the CAT activity in blood with no effect on GSH-pX.