CAJ | 학술논문

目的:研究酒依赖者戒饮期的认知功能、脑电图、脑CT、酒依赖程度和共病的相关因素.方法:32例酒依赖组:确定酒依赖的程度,进行脑电图及头颅CT检查,入组3-4周内进行认知功能检测.酒依赖组分首发组及复饮组,比较两组患者认知功能、头颅CT、脑电图、依赖程度及共病情况.28例健康对照组只做认知功能检查.结果:酒依赖组的言语记忆(t=-2.95,P<0.01)、视觉记忆(t=-4.04,P<0.01)、数字序列测验(t=-2.68,P<0.01)的测验成绩明显低于对照组;执行功能的威斯康星卡片分类测验(WCST)各项测试得分、伦敦塔测验(t=-2.39,P<0.05)及Stroop色词测验(t=-4.80,P<0.01)得分也明显低于对照组.复饮组较首发组的认知功能损害程度严重,且头颅CT及脑电图的异常率较首发组高;脑电图异常及脑CT异常与复饮呈正相关.结论:酒依赖患者戒饮期的认知功能损害仍持续存在,反复饮酒者的认知功能损害程度及头颅CT及脑电图异常高于首发者.
목적:연구주의뢰자계음기적인지공능、뇌전도、뇌CT、주의뢰정도화공병적상관인소.방법:32례주의뢰조:학정주의뢰적정도,진행뇌전도급두로CT검사,입조3-4주내진행인지공능검측.주의뢰조분수발조급복음조,비교량조환자인지공능、두로CT、뇌전도、의뢰정도급공병정황.28례건강대조조지주인지공능검사.결과:주의뢰조적언어기억(t=-2.95,P<0.01)、시각기억(t=-4.04,P<0.01)、수자서렬측험(t=-2.68,P<0.01)적측험성적명현저우대조조;집행공능적위사강성잡편분류측험(WCST)각항측시득분、륜돈탑측험(t=-2.39,P<0.05)급Stroop색사측험(t=-4.80,P<0.01)득분야명현저우대조조.복음조교수발조적인지공능손해정도엄중,차두로CT급뇌전도적이상솔교수발조고;뇌전도이상급뇌CT이상여복음정정상관.결론:주의뢰환자계음기적인지공능손해잉지속존재,반복음주자적인지공능손해정도급두로CT급뇌전도이상고우수발자.
Objective:To investigate the cognitive function of alcoholics at withdrawal period, their brain CT, electroencephalogram, degree of alcohol dependence and comorbidity of other mental diseases. Methods:Thirty two inpatients were divided into two groups, based on their hospitalization times:first hospitalized patients for alcoholism and the relapsed patients, both of whom were tested for alcohol dependence, undertook brain CT, electroencephalogram when they were recruited in hospital. All the patients were measured with some types of cognition scales within the first 3-4 weeks of the study. Twenty eight normal control persons were measured only with cognition scales. Results:The scores of neuropsychological tasks of the patients with alcohol dependence were significantly lower than those of the control group. The scales of all cognition tests except Digit Span Test and Space Span Test were significantly lower than that of the control group. The scales of neuropsychological tasks(except for Visual Memory Test, Digit Span Test and WSCT)of the first hospitalized patients were significantly higher than those of the relapsed patients. Abnormal rates of brain CT and electroencephalogram in the relapsed patients were significantly higher than those in the first hospitalized patients. No differences were observed in dependence degree and comorbidity between the first hospitalized patients and the relapsed patients. Conclusion:There are higher risks of relapse in patients with damaged cognitive function and abnormal brain CT and abnormal electroencephalogram after alcohol withdrawal, which needs us to do something to prevent it as soon as possible.