CAJ | 학술논문

随着定义的统一和认识的深入,输血相关性急性肺损伤(TRALI)已成为输血导致死亡的主要原因之一.TRALI是指输人血液或血液制品后数小时内出现的以急性非心源性肺水肿和低氧血症为主要表现的临床综合征.其确切的发病机制尚未清楚,目前的研究指出TRALI与患者的不良预后和病死率密切相关,尤其对于危重患者.临床上筛选经产妇及含有HLA抗体的血液成分固然可以降低TRALI的发病率,但对预防TRALI更有效的方法仍需进一步探讨.
수착정의적통일화인식적심입,수혈상관성급성폐손상(TRALI)이성위수혈도치사망적주요원인지일.TRALI시지수인혈액혹혈액제품후수소시내출현적이급성비심원성폐수종화저양혈증위주요표현적림상종합정.기학절적발병궤제상미청초,목전적연구지출TRALI여환자적불량예후화병사솔밀절상관,우기대우위중환자.림상상사선경산부급함유HLA항체적혈액성분고연가이강저TRALI적발병솔,단대예방TRALI경유효적방법잉수진일보탐토.
With the unity of definition and increased recognition, transfusion-related acute lung injury (TRALI) has become one of the main reasons of death cause by transfusion. TRALI is the clinical syndrome mainly characterized by acute non-cardiogenic pulmonary edema and hypoxemia within hours after transfusion of blood or blood products. The pathogenesis has not been clear. The present studies indicate that TRALI is closely related to poor prognosis and mortality of patients,especially for critically ill patients. The blood component from multipara or containing HLA antibodies can certainly reduce the incidence of TRALI, but more effective measures to prevent TRALI should be further explored.