中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2009年
1期
25-28
,共4页
汪卫华%赵汉清%白战生%汪广剑%宋梓祥%阎同军%蔡占魁%刘丽%薛蕴庄%仲爱芳%汪莉
汪衛華%趙漢清%白戰生%汪廣劍%宋梓祥%閻同軍%蔡佔魁%劉麗%薛蘊莊%仲愛芳%汪莉
왕위화%조한청%백전생%왕엄검%송재상%염동군%채점괴%류려%설온장%중애방%왕리
精神分裂症%冲动行为%自杀%瘦素%胆固醇
精神分裂癥%遲動行為%自殺%瘦素%膽固醇
정신분렬증%충동행위%자살%수소%담고순
Schizophrenia%Impulsive behavior%Suicide%Leptin%Cholesterol
目的 探讨精神分裂症患者冲动、自杀行为与血浆瘦素及胆固醇之间的相关性.方法 106例精神分裂症首次发病患者用简明精神病评定量表(BPRS)、阳性和阴性症状量表(PANSS)、汉密尔顿抑郁量表(HAMD24)及Beck绝望量表(BHS)进行评定;按有无冲动、自杀行为分为自杀组(24例)、冲动组(31例)、非自杀非冲动组(以下简称患者对照组,51例),32名体检职工为正常对照组,所有入组对象(患者在服药前)测定体质量指数(BMI)、血浆瘦素和总胆固醇.结果 (1)正常对照组[(4.8±0.9)mmol/L]和患者对照组[(4.3±1.1)mmol/L]总胆固醇均高于自杀组[(3.7±1.0)mmol/L]及冲动组[(3.6±1.0)mmoL/L;P<0.05～0.01],而冲动组与自杀组之间、正常对照组与患者对照组之间的差异无统计学意义(P>0.05);正常对照组血浆瘦素[(13.4±6.7)μg/L]高于患者对照组[(8.9±3.8)μg/L]、自杀组[(6.7±2.6)μg/L]及冲动组[(5.6±4.2)μg/L;P<0.05～0.01],患者对照组高于自杀组及冲动组(P<0.05),而自杀组与冲动组的差异无统计学意义(P>0.05).(2)4组的血浆瘦素及总胆固醇均与BMI呈正相关(r=0.49～0.64;P<0.01);自杀组、冲动组的血浆瘦素和总胆固醇与PANSS阳性分、PANSS攻击分、BPRS分、HAMD分、BHS分均呈显著负相关(r=-0.35～-0.72;P<0.05～0.01);患者对照组的血浆瘦素、总胆固醇与PANSS攻击分、BPRS分、HAMD分、BHS分均呈显著负相关r=-0.29～-0.48;P<0.05～0.01).结论 精神分裂症患者的冲动、自杀行为及疾病严重程度与血浆瘦素及总胆固醇有一定的相关性.
目的 探討精神分裂癥患者遲動、自殺行為與血漿瘦素及膽固醇之間的相關性.方法 106例精神分裂癥首次髮病患者用簡明精神病評定量錶(BPRS)、暘性和陰性癥狀量錶(PANSS)、漢密爾頓抑鬱量錶(HAMD24)及Beck絕望量錶(BHS)進行評定;按有無遲動、自殺行為分為自殺組(24例)、遲動組(31例)、非自殺非遲動組(以下簡稱患者對照組,51例),32名體檢職工為正常對照組,所有入組對象(患者在服藥前)測定體質量指數(BMI)、血漿瘦素和總膽固醇.結果 (1)正常對照組[(4.8±0.9)mmol/L]和患者對照組[(4.3±1.1)mmol/L]總膽固醇均高于自殺組[(3.7±1.0)mmol/L]及遲動組[(3.6±1.0)mmoL/L;P<0.05～0.01],而遲動組與自殺組之間、正常對照組與患者對照組之間的差異無統計學意義(P>0.05);正常對照組血漿瘦素[(13.4±6.7)μg/L]高于患者對照組[(8.9±3.8)μg/L]、自殺組[(6.7±2.6)μg/L]及遲動組[(5.6±4.2)μg/L;P<0.05～0.01],患者對照組高于自殺組及遲動組(P<0.05),而自殺組與遲動組的差異無統計學意義(P>0.05).(2)4組的血漿瘦素及總膽固醇均與BMI呈正相關(r=0.49～0.64;P<0.01);自殺組、遲動組的血漿瘦素和總膽固醇與PANSS暘性分、PANSS攻擊分、BPRS分、HAMD分、BHS分均呈顯著負相關(r=-0.35～-0.72;P<0.05～0.01);患者對照組的血漿瘦素、總膽固醇與PANSS攻擊分、BPRS分、HAMD分、BHS分均呈顯著負相關r=-0.29～-0.48;P<0.05～0.01).結論 精神分裂癥患者的遲動、自殺行為及疾病嚴重程度與血漿瘦素及總膽固醇有一定的相關性.
목적 탐토정신분렬증환자충동、자살행위여혈장수소급담고순지간적상관성.방법 106례정신분렬증수차발병환자용간명정신병평정량표(BPRS)、양성화음성증상량표(PANSS)、한밀이돈억욱량표(HAMD24)급Beck절망량표(BHS)진행평정;안유무충동、자살행위분위자살조(24례)、충동조(31례)、비자살비충동조(이하간칭환자대조조,51례),32명체검직공위정상대조조,소유입조대상(환자재복약전)측정체질량지수(BMI)、혈장수소화총담고순.결과 (1)정상대조조[(4.8±0.9)mmol/L]화환자대조조[(4.3±1.1)mmol/L]총담고순균고우자살조[(3.7±1.0)mmol/L]급충동조[(3.6±1.0)mmoL/L;P<0.05～0.01],이충동조여자살조지간、정상대조조여환자대조조지간적차이무통계학의의(P>0.05);정상대조조혈장수소[(13.4±6.7)μg/L]고우환자대조조[(8.9±3.8)μg/L]、자살조[(6.7±2.6)μg/L]급충동조[(5.6±4.2)μg/L;P<0.05～0.01],환자대조조고우자살조급충동조(P<0.05),이자살조여충동조적차이무통계학의의(P>0.05).(2)4조적혈장수소급총담고순균여BMI정정상관(r=0.49～0.64;P<0.01);자살조、충동조적혈장수소화총담고순여PANSS양성분、PANSS공격분、BPRS분、HAMD분、BHS분균정현저부상관(r=-0.35～-0.72;P<0.05～0.01);환자대조조적혈장수소、총담고순여PANSS공격분、BPRS분、HAMD분、BHS분균정현저부상관r=-0.29～-0.48;P<0.05～0.01).결론 정신분렬증환자적충동、자살행위급질병엄중정도여혈장수소급총담고순유일정적상관성.
Objective To investigate the correlation between impulse, suicidal behavior and plasma leptin and total cholesterol in first-episode schizophrenic patients. Methods According to their history of suicide and impulse behavior, 106 first-episode schizophrenic patients were divided into 3 groups: suicide group (n=24), impulse group (n=31) and non-suicide-non-impulse group (n=51), and assessed with the Brief Psychiatric Rating Scale (BPRS), Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Scale (HAMD24) and Beck Hopelessness Scale (BHS), Thirty-two individuals who took part in health examination were selected as health control group. Body mass index (BMI), plasma leptin and total cholesterol were measured from all subjects before taking medication. Results (1) The plasma leptin level was higher in healthy control group[(13.4±6.7) μg/L] than non-suicide-non-impulse group[(8.9±3.8) μg/L], suicide group[(6.7±2.6) μg/L] and impulse group [(5.6±4.2) μg/L; P<0.05-0.01], and with significant differences between non-suicide-non-impulse group, suicide group and impulse group (P<0.05), but no significant difference between suicide group and impulse group (P>0.05). The plasma levels of total cholesterol in healthy control group and non-suicide-non-impulse group were higher than in suicide group and impulse group (P<0.05-0.01), with no significant difference between suicide groupand impulse group (P>0.05), and between healthy control group and non-suicide-non-impulse group (P>0.05). (2) In suicide group and impulse group, plasma leptin and total cholesterol were negatively correlated with PANSS positive score, PANSS attack score, BPRS score, HAMD score and BHS score. Plasma leptin and total cholesterol in non-suicide-non-impulse group were negatively correlated with PANSS attack score, BPRS score, HAMD score and BHS score. Conclusion Impulse and suicidal behavior and illness severity of schizophrenic patients may be correlated with plasma leptin and total cholesterol.
