肿瘤
腫瘤
종류
TUMOR
2010年
3期
261-264
,共4页
肿瘤%白细胞介素-21%T淋巴细胞%B淋巴细胞
腫瘤%白細胞介素-21%T淋巴細胞%B淋巴細胞
종류%백세포개소-21%T림파세포%B림파세포
Neoplasms%Interleukin-21%T-lymphocytes%B-lymphocytes
白细胞介素21(interleukin-21, IL-21) 是新近发现的具有免疫调节活性的细胞因子, 属于IL-2细胞因子家族新成员,主要由活化的CD4~+ T 细胞分泌,IL-21与其受体结合后可调节T细胞、自然杀伤(natural killer,NK)细胞和B细胞的增殖、分化和功能,有效增强机体的天然免疫及获得性免疫.在多种肿瘤模型中已证实,IL-21具有抗肿瘤活性,且Ⅱ期临床试验正在转移性黑素瘤和肾细胞癌中进行,其在恶性肿瘤治疗方面具有广泛的应用前景.本文对IL-21的抗肿瘤作用及其联合其他药物在未来肿瘤免疫治疗中的应用前景进行综述.
白細胞介素21(interleukin-21, IL-21) 是新近髮現的具有免疫調節活性的細胞因子, 屬于IL-2細胞因子傢族新成員,主要由活化的CD4~+ T 細胞分泌,IL-21與其受體結閤後可調節T細胞、自然殺傷(natural killer,NK)細胞和B細胞的增殖、分化和功能,有效增彊機體的天然免疫及穫得性免疫.在多種腫瘤模型中已證實,IL-21具有抗腫瘤活性,且Ⅱ期臨床試驗正在轉移性黑素瘤和腎細胞癌中進行,其在噁性腫瘤治療方麵具有廣汎的應用前景.本文對IL-21的抗腫瘤作用及其聯閤其他藥物在未來腫瘤免疫治療中的應用前景進行綜述.
백세포개소21(interleukin-21, IL-21) 시신근발현적구유면역조절활성적세포인자, 속우IL-2세포인자가족신성원,주요유활화적CD4~+ T 세포분비,IL-21여기수체결합후가조절T세포、자연살상(natural killer,NK)세포화B세포적증식、분화화공능,유효증강궤체적천연면역급획득성면역.재다충종류모형중이증실,IL-21구유항종류활성,차Ⅱ기림상시험정재전이성흑소류화신세포암중진행,기재악성종류치료방면구유엄범적응용전경.본문대IL-21적항종류작용급기연합기타약물재미래종류면역치료중적응용전경진행종술.
Interleukin-21 (IL-21) is a recently discovered cytokine with immunomodulatory activity. It is a new member of the IL-2 family and mainly secreted by the activated CD4~+ T cells. IL-21 can promote proliferation, differentiation and function of T cells, natural killer (NK) cells, and B cells after binding with its receptor, thereby effectively strengthen the innate immunity and acquired immunity. The antitumor activity of IL-21 has been demonstrated in several tumor models. Its phase Ⅱ trials is being carried out in metastatic melanoma and renal cell carcinoma. IL-21 has a broad application prospects in the treatment of malignant tumors. Here, we review the anti-tumor effects of IL-21 and the application foreground of combination of IL-21 with other drugs in future tumor immunotherapy.
