CAJ | 학술논문

目的观察丹红合剂对家兔血小板聚集的影响.方法采用随机数字表法将40只大耳白家兔随机分为5组,每组8只,分别为空白对照组(予等容量的0.5％羧甲基纤维素纳),丹红合剂5、2.5、1.25 g/kg组,阿司匹林0.025 g/kg组.各组均按1ml/kg容积灌胃,1次/d,连续给药8d.于末次给药1h后心脏取血,用二磷酸腺苷(ADP)、胶原、花生四烯酸(AA)3种诱导剂进行血小板聚集实验.结果丹红合剂5、2.5、1.25 g/kg组对ADP诱导的家兔血小板聚集率的抑制率分别为9.4％、5.1％、0.6％,对胶原诱导的家兔血小板聚集抑制率分别为34.5％、11.1％、5.6％；对花生四烯酸(AA)诱导的家兔血小板聚集抑制率分别为21.4％、11.6％、2.3％.结论丹红合剂具有抑制血小板聚集作用.
목적 관찰단홍합제대가토혈소판취집적영향.방법 채용수궤수자표법장40지대이백가토수궤분위5조,매조8지,분별위공백대조조(여등용량적0.5％최갑기섬유소납),단홍합제5、2.5、1.25 g/kg조,아사필림0.025 g/kg조.각조균안1ml/kg용적관위,1차/d,련속급약8d.우말차급약1h후심장취혈,용이린산선감(ADP)、효원、화생사희산(AA)3충유도제진행혈소판취집실험.결과 단홍합제5、2.5、1.25 g/kg조대ADP유도적가토혈소판취집솔적억제솔분별위9.4％、5.1％、0.6％,대효원유도적가토혈소판취집억제솔분별위34.5％、11.1％、5.6％；대화생사희산(AA)유도적가토혈소판취집억제솔분별위21.4％、11.6％、2.3％.결론 단홍합제구유억제혈소판취집작용.
Objective To study the effects of Danhong mixture on platelet aggregation of rabbits.Methods 40 rabbits were randomly divided into 5 groups,8 rabbits in each group,of blank control group (treated with 0.5％ sodium carboxy methyl cellulose of the same volume),Danhong mixture of 5,2.5,1.25 g/kg group,aspirin group (treated with 0.025 g/kg aspirin).Each group was performed gastric lavage according to the ration of lml/kg,once daily,for continuous 8 days.Blood was obtained from heart 1 hour after last administration,then adenosine diphosphate (ADP),collagen,arachidonic acid (AA) were used for platelet aggregation test.Results Inhibition rate of Danhong mixture (5,2.5,1.25 g/kg) on ADP induced rabbit platelet aggregation were 9.4％,5.1％,and 0.6％ respectively,on collagen induced platelet aggregation were 34.5％,11.1％,and 5.6％; on AA induced platelet aggregation were 21.4％,11.6％,and 2.3％ respectively.Conclusion Danhong mixture had inhibitive action on platelet aggregation.