CAJ | 학술논문

目的了解肝衰竭合并曲霉菌感染的临床特征.方法收集我院1985年1月-2006年6月所有合并真菌感染的肝衰竭患者507例,以合并曲霉菌感染的肝衰竭患者104例为主要分析对象.两组间数据的比较用配对t检验,率的比较用χ2检验. 结果 507例肝衰竭合并真菌感染患者中,曲霉菌感染104例(20.5%).抗真菌治疗的有效率和基础疾病的治愈好转率,曲霉菌感染患者分别为36.5%和26.0%,非曲霉菌感染患者分别为57.8%和36.7%,P=0.000和P=0.049.共分离出曲霉菌108株,烟曲霉菌最为多见,共53株(49.1%),肺脏为曲霉菌主要感染部位90例次(63.8%),感染后临床表现常不典型.在抗真菌治疗有效的患者,肝功能呈好转趋势. 结论肝衰竭合并曲霉菌感染的诊断、治疗困难.对于临床上怀疑有曲霉菌感染的肝衰竭患者,早期积极治疗有助于患者恢复.
목적 료해간쇠갈합병곡매균감염적림상특정.방법 수집아원1985년1월-2006년6월소유합병진균감염적간쇠갈환자507례,이합병곡매균감염적간쇠갈환자104례위주요분석대상.량조간수거적비교용배대t검험,솔적비교용χ2검험. 결과 507례간쇠갈합병진균감염환자중,곡매균감염104례(20.5%).항진균치료적유효솔화기출질병적치유호전솔,곡매균감염환자분별위36.5%화26.0%,비곡매균감염환자분별위57.8%화36.7%,P=0.000화P=0.049.공분리출곡매균108주,연곡매균최위다견,공53주(49.1%),폐장위곡매균주요감염부위90례차(63.8%),감염후림상표현상불전형.재항진균치료유효적환자,간공능정호전추세. 결론간쇠갈합병곡매균감염적진단、치료곤난.대우림상상부의유곡매균감염적간쇠갈환자,조기적겁치료유조우환자회복.
Objective To study the clinical characteristics of hepatic failure with aspergillosis. Methods The data of hepatic failure patients with fungal infection hospitalized in our hospital form January 1985 to June 2006 were collected. This research mainly focused on the clinical characteristics of the patients co-infected with aspergillosis. Results The occurrence of aspergillosis was 20.5% (104 cases) among 507 hepatic failure patients with fungal infection. Compared with other fungal infection in hepatic failure patients, the effective rate of antifungal therapy and the improvement rate of underlying disease were worse in patients with aspergilus infection (36.5% vs 57.8%, P = 0.000; 26.0% vs 36.7%, P = 0.049). Aspergillus fumigatus was the most common species among 108 fungal species. The species next to Aspergillus fumigatus were Aspergillus niger and Aspergillus flavus. The mainly infected organ was lung and its clinical manifestation was atypical. Liver function could be improved with effective anti-fungus-therapy. Conclusions Diagnosis and treatment of aspergillosis is difficult in hepatic failure patients co-infected with aspergillosis. Early and effective antifungal therapy is helpful to the recovery of liver function in the hepatic failure patients suspected with aspergillosis co-infection.