中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2010年
11期
1729-1731
,共3页
谢锋%张正文%李振鲁%侴海燕%李磊%李昊
謝鋒%張正文%李振魯%侴海燕%李磊%李昊
사봉%장정문%리진로%호해연%리뢰%리호
甲母痣%谷胱苷肽S转移酶M1%谷胱苷肽S转移酶T1
甲母痣%穀胱苷肽S轉移酶M1%穀胱苷肽S轉移酶T1
갑모지%곡광감태S전이매M1%곡광감태S전이매T1
Nail matrix naevus%Glutathione S transferase M1%Glutathione S transferase T1
目的 探讨谷胱苷肽S转移酶M1(GSTM1)、谷胱苷肽S转移酶T1(GSTT1)基因缺失与甲母痣恶变之间的关系.方法 采用聚合酶链反应(PCR)技术检测77例甲母痣恶变患者和107例甲母痣患者中GSTM1、GSTT1基因缺失的频率.结果 病例组GSTM1基因缺失的频率为58.4%,显著高于对照组的缺失频率42.1%(x2=4.811,P＜0.05),危险度分析得出OR=1.938,95%CI为1.070～3.509;病例组GSTT1基因缺失的频率为57.1%,接近对照组50.5%的水平(x2=0.802,P＞0.05).联合分析表明两基因在甲母痣恶变发生中具有协同作用.结论 GSTM1基因缺失或GSTM1、GSTT1基因联合缺失在甲母痣恶变患者中发生频率增高,能增加甲母痣恶变的易感性.
目的 探討穀胱苷肽S轉移酶M1(GSTM1)、穀胱苷肽S轉移酶T1(GSTT1)基因缺失與甲母痣噁變之間的關繫.方法 採用聚閤酶鏈反應(PCR)技術檢測77例甲母痣噁變患者和107例甲母痣患者中GSTM1、GSTT1基因缺失的頻率.結果 病例組GSTM1基因缺失的頻率為58.4%,顯著高于對照組的缺失頻率42.1%(x2=4.811,P＜0.05),危險度分析得齣OR=1.938,95%CI為1.070～3.509;病例組GSTT1基因缺失的頻率為57.1%,接近對照組50.5%的水平(x2=0.802,P＞0.05).聯閤分析錶明兩基因在甲母痣噁變髮生中具有協同作用.結論 GSTM1基因缺失或GSTM1、GSTT1基因聯閤缺失在甲母痣噁變患者中髮生頻率增高,能增加甲母痣噁變的易感性.
목적 탐토곡광감태S전이매M1(GSTM1)、곡광감태S전이매T1(GSTT1)기인결실여갑모지악변지간적관계.방법 채용취합매련반응(PCR)기술검측77례갑모지악변환자화107례갑모지환자중GSTM1、GSTT1기인결실적빈솔.결과 병례조GSTM1기인결실적빈솔위58.4%,현저고우대조조적결실빈솔42.1%(x2=4.811,P＜0.05),위험도분석득출OR=1.938,95%CI위1.070～3.509;병례조GSTT1기인결실적빈솔위57.1%,접근대조조50.5%적수평(x2=0.802,P＞0.05).연합분석표명량기인재갑모지악변발생중구유협동작용.결론 GSTM1기인결실혹GSTM1、GSTT1기인연합결실재갑모지악변환자중발생빈솔증고,능증가갑모지악변적역감성.
Objective To study the relationship between the deletion of glutathione S transferase M1 ( GSTM1), glutathione S transferase T1 ( GSTT1 ) and susceptibility to Malignant of nail matrix naevus and its mechanism. Methods Using the method of PCR to detect the genotypes of GSTM1 and GSTT1 in 77 Malignant of nail matrix naevus patients and 107 nail matrix naevns people. Results There were 58.4% (45/77) malignant patients with GSTM1 null genotype in all cases and 42. 1% (45/107) persons with GSTM1 null genotype in the nail matrix naevus people, and there was significant difference between the two groups (x2 = 4. 811, P ＜ 0. 05 ), and its OR was 1. 938 (95% CI 1. 095-3. 581 ); There were 57. 1% (44/77) malignant patients with GSTT1 null genotype in all cases and 50. 5% (54/107) persons with GSTT1 null genotype in the nail matrix naevus people, and there wasnt significant difference between the two groups (x2 = 0. 802, P ＞ 0. 05 ) ;There were 26 cases with GSTM1 null/GSTT1 null genotype in malignant patients which was significantly higher than those in the nail matrix naevus people, and its OR was2.451 (95%CI 1.067-5.633). Conclusion GSTM1 null genotype and GSTM1/GSTT1 combined null genotype laid in much more malignant of nail matrix naevus patients than nail matrix naevus people,and it could highly increase the risk of malignant of nail matrix naevus occurrence.
