中华肝胆外科杂志
中華肝膽外科雜誌
중화간담외과잡지
CHINESE JOURNAL OF HEPATOBILIARY SURGERY
2010年
9期
655-658
,共4页
邱应和%刘辰%易滨%罗祥基%谭蔚锋%程庆宝%于勇%冯飞灵%姜小清%吴孟超
邱應和%劉辰%易濱%囉祥基%譚蔚鋒%程慶寶%于勇%馮飛靈%薑小清%吳孟超
구응화%류신%역빈%라상기%담위봉%정경보%우용%풍비령%강소청%오맹초
胆囊肿瘤%外科根治术
膽囊腫瘤%外科根治術
담낭종류%외과근치술
Gallbladder neoplasms%Radical resection
目的 探讨不同手术方式对进展期胆囊癌预后的影响,并对影响其预后的因素进行分析.方法 对第二军医大学东方肝胆外科医院2002年6月至2008年6月收治的181例进展期胆囊癌的临床病理资料进行回顾分析,应用SPSS 16.0统计软件包进行统计学处理.结果 胆囊癌的总体中位生存时间为6个月,其中胆囊癌根治切除组(R0)为19.5个月,与R1切除组、R2切除组、姑息手术组间差异有显著意义(P＜0.01);对Nevin不同病理分期手术R0发现,NevinⅡ、Ⅲ、Ⅳ、Ⅴ期RO切除率分别为95.5%、62.2%、14.1%及4.7%,各组间比较均具有显著差异(P＜0.01);Cox多因素分析显示肿瘤的Nevin病理分期、总胆红素、CA-199和治疗方法与胆囊癌的预后显著相关.结论 外科根治切除有助于提高NerinⅡ～Ⅳ进展期胆囊癌的生存率,显著改善其预后.
目的 探討不同手術方式對進展期膽囊癌預後的影響,併對影響其預後的因素進行分析.方法 對第二軍醫大學東方肝膽外科醫院2002年6月至2008年6月收治的181例進展期膽囊癌的臨床病理資料進行迴顧分析,應用SPSS 16.0統計軟件包進行統計學處理.結果 膽囊癌的總體中位生存時間為6箇月,其中膽囊癌根治切除組(R0)為19.5箇月,與R1切除組、R2切除組、姑息手術組間差異有顯著意義(P＜0.01);對Nevin不同病理分期手術R0髮現,NevinⅡ、Ⅲ、Ⅳ、Ⅴ期RO切除率分彆為95.5%、62.2%、14.1%及4.7%,各組間比較均具有顯著差異(P＜0.01);Cox多因素分析顯示腫瘤的Nevin病理分期、總膽紅素、CA-199和治療方法與膽囊癌的預後顯著相關.結論 外科根治切除有助于提高NerinⅡ～Ⅳ進展期膽囊癌的生存率,顯著改善其預後.
목적 탐토불동수술방식대진전기담낭암예후적영향,병대영향기예후적인소진행분석.방법 대제이군의대학동방간담외과의원2002년6월지2008년6월수치적181례진전기담낭암적림상병리자료진행회고분석,응용SPSS 16.0통계연건포진행통계학처리.결과 담낭암적총체중위생존시간위6개월,기중담낭암근치절제조(R0)위19.5개월,여R1절제조、R2절제조、고식수술조간차이유현저의의(P＜0.01);대Nevin불동병리분기수술R0발현,NevinⅡ、Ⅲ、Ⅳ、Ⅴ기RO절제솔분별위95.5%、62.2%、14.1%급4.7%,각조간비교균구유현저차이(P＜0.01);Cox다인소분석현시종류적Nevin병리분기、총담홍소、CA-199화치료방법여담낭암적예후현저상관.결론 외과근치절제유조우제고NerinⅡ～Ⅳ진전기담낭암적생존솔,현저개선기예후.
Objective To analyze the characteristics and prognostic factors of gallbladder carcinoma and investigate the measures of various modus operandi. Methods The clinicopathological data of 181 patients with advanced gallbladder carcinoma treated in our hospital from June 2002 to June 2008 were retrospectively analyzed. SPSS16. 0 software package was used for statistical analysis.Results The overall median survival rate of the 181 patients with gallbladder carcinoma was 6 months. The median survival rate after radical resection for gallbladder carcinoma was 19.5 months,which was remarkably higher than other R1 resection, R2 resection and palliative operation groups (P ＜0. 01) The RO resection rates were 95.5%, 62. 2%, 14.1% and 4.7%, respectively based on different pathological stages of Nevin( Ⅱ , Ⅲ, Ⅳ, and Ⅴ ). There were significant differences among all groups (P＜0.01). The Cox multivariate analysis revealed that pathological stages of Nevin, total bilirubin, CA-199 and therapeutic method had significantly higher risk ratios for gallbladder carcinoma.Conclusion Radical resection may help to improve the survival rate and prognosis of advanced gallbladder carcinoma.
