CAJ | 학술논문

目的运用优化的基于体素的形态学方法(VBM)研究中国汉族人群强迫症(OCD)患者脑灰质结构异常以及与临床症状的相关性.方法选取20例OCD患者和年龄、性别匹配的20名正常对照者,进行高分辨3.0 T MR扫描,在统计参数图(SPM)5软件中采用优化的VBM方法处理三维T1结构像,然后比较OCD患者与正常对照组脑灰质体积的差异.并提取代表OCD患者有差异脑区体积平均值的特征值,与临床评分以及病程进行Pearson相关性分析.结果与正常对照组相比,经过错误发现率(FDR)校正,OCD患者双侧丘脑以及左侧小脑的灰质体积增大,同时没有发现OCD患者相对正常对照组灰质体积减小的区域.代表OCD患者左侧丘脑体积特征值为0.5782～0.8890,平均为0.6813±0.0718,右侧丘脑体积特征值为0.5546～0.9062,平均为0.6869±0.0808,两者呈正相关(r=0.94,P＜0.01).结论运用优化的VBM方法发现,OCD患者双侧丘脑及左侧小脑灰质体积增加,为OCD患者临床症状学的差异提供了脑结构的神经影像学证据,提示双侧丘脑以及小脑在OCD发生的病理生理机制当中具有重要作用.
목적 운용우화적기우체소적형태학방법(VBM)연구중국한족인군강박증(OCD)환자뇌회질결구이상이급여림상증상적상관성.방법 선취20례OCD환자화년령、성별필배적20명정상대조자,진행고분변3.0 T MR소묘,재통계삼수도(SPM)5연건중채용우화적VBM방법처리삼유T1결구상,연후비교OCD환자여정상대조조뇌회질체적적차이.병제취대표OCD환자유차이뇌구체적평균치적특정치,여림상평분이급병정진행Pearson상관성분석.결과 여정상대조조상비,경과착오발현솔(FDR)교정,OCD환자쌍측구뇌이급좌측소뇌적회질체적증대,동시몰유발현OCD환자상대정상대조조회질체적감소적구역.대표OCD환자좌측구뇌체적특정치위0.5782～0.8890,평균위0.6813±0.0718,우측구뇌체적특정치위0.5546～0.9062,평균위0.6869±0.0808,량자정정상관(r=0.94,P＜0.01).결론 운용우화적VBM방법발현,OCD환자쌍측구뇌급좌측소뇌회질체적증가,위OCD환자림상증상학적차이제공료뇌결구적신경영상학증거,제시쌍측구뇌이급소뇌재OCD발생적병리생리궤제당중구유중요작용.
Objective To explore changes of gray matter volume in patients with obsessivecompulsive disorder (OCD) in Chinese Han population using optimized voxel-based morphometry (VBM) ,and investigate its relationship with clinical symptoms. Methods Twenty patients with OCD and 20 age,sex and handedness matched healthy controls were scanned using 3D-T1 images on a 3.0 T MR system. The high resolution T1WI was preprocessed according to the optimized VBM protocol in Statistical Parametric Mapping (SPM5). Two-sample t test was performed to characterize the differences of the gray matter volume (GMV) between the OCD patients and healthy controls, and the correlations between the GMV and symptom severity and cumulative illness duration were examined using Pearson correlation in SPSS 16. 0, respectively.Results Compared to controls, OCD patients demonstrated increased GMV in left thalamus, right thalamus and left cerebellum after false discovery rate (FDR) correction. No areas of significantly decreased GMV was observed in OCD patients in relative to healthy controls. The mean eigenvalue ranged from 0. 5782 to 0. 889 representing the left thalamus volume of OCD patients was 0. 6813 ± 0. 0718, and that ranged from 0. 5546 to 0. 9062 was 0. 6869 ± 0. 0808 tor right thalamus. The mean eigenvalues were positively correlated in bilateral thalamus (r = 0. 94, P ＜ 0. 01). Conclusion Using optimized VBM, the current research indicates that the pathophysiology of OCD is associated with GMV abnormalities not only in corticostriato-thalamo-cortical (CSTC) circuit, but also in the cerebellum.