CAJ | 학술논문

目的探讨育龄期多囊卵巢综合征(PCOS)患者的糖代谢异常和胰岛素抵抗.方法选择育龄期PCOS患者168例,分为肥胖PCOS组78例和非肥胖PCOS组90例,正常对照组100例,对比临床表现及检测内分泌激素、空腹血糖、空腹胰岛素、服糖后2 h血糖及2 h胰岛素.结果育龄期PCOS患者的月经周期、多毛、痤疮、B超提示卵巢增大、卵巢多囊性改变、有不孕史与对照组比较,差异均有显著性(P＜0.05),育龄期PCOS组的血清LH、T与对照组比较,差异有显著性(P＜0.05).育龄期肥胖P-COS组的空腹血糖、服糖后2 h血糖、空腹胰岛素、服糖后2 h胰岛素与对照组比较,差异均有显著性(P＜0.05).结论早期出现月经稀发、BMI升高的患者是否存在PCOS,值得重视.育龄期PCOS患者尤其肥胖型要高度重视糖代谢异常及胰岛素抵抗,以决定是否采取干预措施,避免出现远期并发症而对P-COS患者造成健康威胁.
목적 탐토육령기다낭란소종합정(PCOS)환자적당대사이상화이도소저항.방법 선택육령기PCOS환자168례,분위비반PCOS조78례화비비반PCOS조90례,정상대조조100례,대비림상표현급검측내분비격소、공복혈당、공복이도소、복당후2 h혈당급2 h이도소.결과 육령기PCOS환자적월경주기、다모、좌창、B초제시란소증대、란소다낭성개변、유불잉사여대조조비교,차이균유현저성(P＜0.05),육령기PCOS조적혈청LH、T여대조조비교,차이유현저성(P＜0.05).육령기비반P-COS조적공복혈당、복당후2 h혈당、공복이도소、복당후2 h이도소여대조조비교,차이균유현저성(P＜0.05).결론 조기출현월경희발、BMI승고적환자시부존재PCOS,치득중시.육령기PCOS환자우기비반형요고도중시당대사이상급이도소저항,이결정시부채취간예조시,피면출현원기병발증이대P-COS환자조성건강위협.
Objective To investigate glucose metabolism and insulin resistance in the adult women with polycystic ovary syndrome(PCOS).Methods Seventy-eight cases of obese women witb PCOS,ninety cases of non-obese women with PCOS and one hundred cases of control group were reviewed regarding clinical features,endocrinal hormone,fasting glucose,fasting insulin,2 h postprandial glucose and 2 h postprandial insulin.Results The menstrual cycle,Hirsutism,acne,ultrasonography suggested ovarian increase,polycystic ovary change and infertility of adult women with PCOS were significantly different compared with the control group(P ＜ 0.05).And the fasting glucose,2 h postprandial glucose,fasting insulin,2 h postprandial insulin of the obese group were also significantly higher compared with the control group (P ＜ 0.05).Conclusion Attention would be paid to patients with early oligomenorrhea and high BMI for PCOS diagnosis.Adult women with PCOS especially the obese should check abnormal glucose metabolism and insulin resistance to determine whether actions should be taken to avoid the menace of long term complication.